Probiotic-Pro12™

Probiotic-Pro12™

Advanced Multi Strain Formula

60 Vegetarian Capsules ( SKU: 9456, NPN: 80038284 )

Benefits

  • A multi strain blend more closely approximates the normal composition of intestinal flora and ensures balance to the entire intestinal tract
    • 8 lactobacilli and 4 bifidobacteria species for ultimate GI health
  • Provides 9 human origin strains, 2 dairy and one vegetable origin strain
    • Each strain has specific inhibitive functions against pathogenic and putrefactive microorganisms throughout the entire GI tract
    • Each strain is resistant to gastric acidity as well as high bile concentrations
  • High potency with at least 12 billion cfu per capsule at time of expiry (guaranteed minimum 18 billion active cells at manufacturing date)
  • Includes prebiotic FOS inulin to promote probiotic growth
  • The high quality lactic acid bacteria requires considerable care at all times, therefore over 20 stringent quality control measures are implemented to ensure strain consistency and viability right up until finished product

Feature Summary

The microbial ecosystem in the gastrointestinal (GI) tract has emerged as a “virtual organ system”, with growing recognition of its diverse significance in both health maintenance and disease prevention.1 GI microbiota play a critical role in maintaining homeostasis of the innate and cell-mediated immune system and enhance intestinal barrier function through a number of mechanisms, including toxin metabolism, tight junction protein phosphorylation and inflammation reduction.2 Research has clearly shown the importance of intestinal bacteria not just for maintaining optimal gastrointestinal health, but also for chronic and systemic health conditions such as Type 2 diabetes, obesity and other inflammatory or autoimmune diseases.3,4,5,6

Probiotics have multifactorial benefits, by modulating gut immune responses and intestinal barrier functions in a strain and dose-dependent manner. Additionally, mixtures of probiotics appear to have greater efficacy than single strains, perhaps because of synergistic activity or because individuals react differently to various strains.7,8,9,10 Probiotic-Pro12 contains 12 bacterial species, each chosen because they can withstand both gastric acid and high bile concentrations, and for their proven benefit in clinical research, mediated via individual mechanisms of action.

Medicinal Ingredients

Serving Size: 1 Vegetarian Capsule
Servings per Container: 60

Each Capsule Contains:
Lactobacillus casei (HA-108) ...................................................3.00 billion cfu
Lactobacillus rhamnosus (HA-111) .......................................... 1.44 billion cfu
Bifidobacterium breve (HA-129) .............................................. 1.20 billion cfu
Bifidobacterium longum (HA-135) ........................................... 1.20 billion cfu
Lactobacillus acidophilus (HA-122) .........................................1.20 billion cfu
Lactobacillus plantarum (HA-119) .......................................... 1.20 billion cfu
Lactobacillus rhamnosus (HA-114) .......................................... 1.20 billion cfu
Bifidobacterium bifidum (HA-132)............................................ 0.60 billion cfu
Lactobacillus fermentum (HA-179) .......................................... 0.60 billion cfu
Lactobacillus salivarius (HA-118) ........................................... 0.12 billion cfu
Lactobacillus paracasei (HA-196) ........................................... 0.12 billion cfu
Bifidobacterium lactis (HA-194) .............................................. 0.12 billion cfu
cfu: colony forming units

*Guaranteed minimum 12 billion active cells per capsule at expiry date.
Guaranteed minimum 18 billion active cells at manufacturing date

Non-Medicinal Ingredients

Maltodextrin, vegetarian capsule (carbohydrate gum [cellulose], purified water), FOS fructooligosaccharides (naturally occurring complex fructose molecules derived from beets), inulin (chicory), vegetable grade magnesium stearate (lubricant), silica, ascorbic acid.

Allergens:

Contains no artificial preservatives, colours or sweeteners and no corn, starch, wheat or gluten. Sealed for your protection. Do not use if seal is broken. *Requires refrigeration for maximum potency.

Contraindications

Do not use if you are experiencing nausea, fever, vomiting, bloody diarrhea or severe abdominal pain. Do not use if you have an immune-compromised condition (e.g., AIDS, lymphoma, patients undergoing long-term corticosteroid treatment). Keep out of reach of children.

Drug Interactions

No known drug interactions exist. Separation by at least 2 hours from antibiotic use may improve the efficacy of Probiotic-Pro12.

  1. Evans JM1, Morris LS, Marchesi JR. The gut microbiome: the role of a virtual organ in the endocrinology of the host. J Endocrinol. 2013 Aug 28;218(3):R37-47. doi: 10.1530/JOE-13-0131. Print 2013 Sep.
  2. Ng SC, Hart AL, Kamm MA Mechanisms of action of probiotics: recent advances. Inflamm Bowel Dis. 2009 Feb;15(2):300-10.
  3. Ley RE, Turnbaugh PJ, Klein S, et al. Microbial ecology: human gut microbes associated with obesity. Nature. 2006 Dec 21;444(7122):1022-3.
  4. Othman M, Agüero R, Lin HC. Alterations in intestinal microbial flora and human disease. Curr Opin Gastroenterol. 2008 Jan;24(1):11-6.
  5. Sanz Y1, Moya-Pérez A. Microbiota, inflammation and obesity. Adv Exp Med Biol. 2014;817:291-317. doi: 10.1007/978-1-4939-0897-4_14.
  6. Vieira SM1, Pagovich OE, Kriegel MA. Diet, microbiota and autoimmune diseases. Lupus. 2014 May;23(6):518-26. doi: 10.1177/0961203313501401.
  7. Williams EA1, Stimpson J, Wang D, et al. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2009 Jan;29(1):97-103. doi: 10.1111/j.1365-2036.2008.03848.x.
  8. Khalesi S1, Sun J2, Buys N1, Jayasinghe R1. Effect of Probiotics on Blood Pressure : A Systematic Review and Meta-Analysis of Randomized, Controlled Trials. Hypertension. 2014 Jul 21. pii: HYPERTENSIONAHA.114.03469. [Epub ahead of print]
  9. Chapman CM1, Gibson GR, Rowland I. In vitro evaluation of single- and multi-strain probiotics: Inter-species inhibition between probiotic strains, and inhibition of pathogens. Anaerobe. 2012 Aug;18(4):405-13. doi: 10.1016/j.anaerobe.2012.05.004. Epub 2012 Jun 4.
  10. Timmerman HM1, Koning CJ, Mulder L, et al. Monostrain, multistrain and multispecies probiotics--A comparison of functionality and efficacy. Int J Food Microbiol. 2004 Nov 15;96(3):219-33.