Phosphatidylserine

Phosphatidylserine

Supports Cognitive Function

60 Softgels ( SKU: 9273, NPN: 80044225 )

Benefits

  • Each capsule provides 100 mg phophatidylserine, allowing for easy and clinically relevant dosing
  • Also contains naturally occurring phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), all of which contribute to cellular and lipid bilayer function
  • Lipid base provides superior bioavailability
  • Phosphatidylserine is from a non-genetically modified (non-GMO), 100% soy free, and animal-free source (derived from sunflower oil)

Feature Summary

Phosphatidylserine is the most abundant phospholipid in the brain. Along with other phospholipids, phosphatidylserine plays important roles in the structure and fluidity of cell membranes, intercellular communication and protection of cells from damage produced by free radicals.1,2,3 Due to its presence in the brain, the effects of phosphatidylserine on the central nervous system have been widely studied.4 Importantly, clinical studies suggest phosphatidylserine supports cognitive functions which tend to decline with age such as memory, learning, concentration and vocabulary.5,6,7 In addition to this role in age-related cognitive decline, phosphatidylserine has been used in Alzheimer’s disease,1 attention deficit-hyperactivity disorder (ADHD),8 depression9 and improving mental function in young people. In a double-blind placebo-controlled trial, the combination of phosphatidylserine with DHA showed improvement in cognitive performance in non-demented elderly with memory complaints. Specifically, verbal immediate recall was significantly improved in the treatment group, and post-hoc analysis revealed that a subset of participants with relatively good cognitive performance at baseline had significant treatment-associated improvements in immediate and delayed verbal recall, learning abilities and time to copy complex figure.10 In the past, commercial sources of phosphatidylserine have been derived from animal sources. However, enhanced technology has enabled the development of a plant-based source of this important nutrient. Phosphatidylserine by Bioclinic Naturals is made from Sharp-PS Green, which is derived from non-GMO sunflower oil and is 100% soy free.

Medicinal Ingredients

Serving Size: 1 Softgel
Servings per Container: 60

Each Softgel Contains:
Phosphatidylserine (Helianthus annuus) (seed)............................100 mg
(From 565 mg non-GMO sunflower lecithin complex)
Also contains naturally occurring phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE).

Non-Medicinal Ingredients

Softgel (gelatin, glycerin, purified water), non-GMO sunflower oil.

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Keep out of reach of children.

Drug Interactions

As phosphatidylserine is believed to increase acetylcholine levels, conjunctive use with acetylcholinesterase inhibitors and cholinergic drugs may increase acetylcholine levels and may cause cholinergic adverse effects. In addition, conjunctive use with anticholinergic drugs may decrease the effectiveness of these agents.6,12,13

  1. Phosphatidylserine Monograph. Alternative Medicine Review. 2008;13(3):245-247.
  2. Latorraca S, Piersanti P, Tesco G, et al. Effect of phosphatidylserine on free radical susceptibility in human diploid fibroblasts. J Neural Transm Park Dis Dement Sect. 1993;6:73-77.
  3. Richter Y, Herzog Y, Cohen T, Steinhart Y. The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study. Clin Interv Aging. 2010;5:313–316.
  4. Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T. Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints. J Clin Biochem Nutr. 2010 November;47(3):246–255.
  5. Crook TH, Tinklenberg J, Yesavage J, Petrie W, Nunzi MG, Massari DC. Effects of Phosphatidylserine in Age-Associated Memory Impairment. Neurology. 1991;41:644-649.
  6. Crook T, Petrie W, Wells C, Massari DC. Effects of Phosphatidylserine in Alzheimer’s Disease. Psychopharmacology Bulletin. 1992;28(1):61-66.
  7. Cenacchi T, Bertoldin T, Farina C, Fiori MG, Crepaldi, and participating investigators. Cognitive Decline in the Elderly: A Double-Blind Placebo-Controlled Multicenter Study on Efficacy of Phosphatidylserine Administration. Aging Clinical Experimental Research. 1993;5(2):123-133.
  8. Vaisman N, Kaysar N, Zaruk-Adasha Y, et al. Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids. Am J Clin Nutr. 2008;87:1170-1180.
  9. Maggioni M, Picotti GB, Bondiolotti GP, et al. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand. 1990;81:265-70.
  10. Vakhapova V, Cohen T, Richter Y, Herzog Y, Korczyn AD. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. Dement Geriatr Cogn Disord. 2010;29(5):467-74.
  11. Nunzi M, Guidolin D, Petrelli L, et al. Behavioral and morpho-functional correlates of brain aging: a preclinical study with phosphatidylserine. In: Bazan NG, ed. Neurobiology of Essential Fatty Acids. New York, NY: Plenum Press; 1992;393-398.
  12. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem. 2000;275:35215-23.
  13. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl). 1989;99:316-21.