Digest-ProGD®

Digest-ProGD®

Digestive Enzymes

60 Vegetarian Capsules ( SKU: 9501, NPN: 80055226 )

Benefits

  • Contains essential proteases I, II, III, IV and IV, stable throughout the pH range of the digestive tract
  • Each capsule delivers a standardized level of DPP-IV activity and is shown to survive the harsh environment of the stomach
  • Hydrolyzes difficult-to-digest proline-containing peptides such as gluten and casein
  • Contains amylase and glucoamylase that assist in the hydrolysis of carbohydrates as well as the enzyme lactase
  • Provides alpha-galactosidase for the digestion of oligosaccharides found in beans, other legumes and cruciferous vegetables
  • Suitable for vegetarians/vegans, and gluten and casein free diets

Feature Summary

Digest-ProGD is a broad spectrum proprietary enzyme blend, providing unique support for the digestion of gluten and dairy proteins, as well as lactose, other carbohydrates, proteins and fats. It contains Dipeptidyl peptidase IV (DPP-IV), a multifunctional serine protease that targets proline containing peptides, such as those found in gliadin and casein, which are both proteolytically resistant proteins.1,2,3 DPP-IV is thought to be one of the rate limiting enzymes responsible for the digestion of these proteins. It is known to be found in lower amounts in the intestinal mucosa of individuals with celiac disease and to have an inverse correlation with the level of mucosal damage among those with and without celiac disease.4,5 The antigenic and immunomodulatory proline-rich proteins found in gluten are thought to trigger an inflammatory response in patients with either celiac disease or gluten sensitivity, often due to inadvertent gluten exposure, even for those on a gluten free diet.6 Digest-ProGD provides comprehensive digestive support, containing multiple proteases as well as enzymes necessary for lipid and carbohydrate metabolism.

Medicinal Ingredients

Serving Size: 1 Vegetarian Capsule
Servings per Container: 60

Each Capsule Contains:
Proprietary Enzyme Blend ................................................................. 375 mg
Fungal Protease (Aspergillus flavus var. oryzae) (whole)..............247.5 mg (33,750 FCC HUT)
Bacterial Protease (Bacillus subtilis) (whole cell)........................9.375 mg (937.5 FCC PC)
Serratiopeptidase (Serratia marcescens) (whole cell) ..................37.5 mg (3,750 SU)
Bromelain (Ananas comosus var. comosus) (stem)....................2.344 mg (37,500 FCC PU)
Papain (Carica papaya) (fruit)...................................................1.2375 mg (37,500 FCC PU)
Cellulase (Trichoderma reesei) (whole).........................................0.75 mg (75 FCC CU)
Lactase (Aspergillus flavus var. oryzae) (whole) .........................4.275 mg (153.75 FCC ALU)
Alpha-Amylase (Aspergillus flavus var. oryzae) (whole) ............18.75 mg (1875 FCC DU)
Alpha-Amylase (Bacillus subtilis) (whole cell) ..............................37.5 mg (375 FCC BAU)
Glucoamylase (Aspergillus niger) (whole)...................................11.25 mg (11.25 FCC AGU)
Lipase (Candida rugosa) (whole)............................................. 0.9375 mg (112.5 FCC LU)
Alpha-Galactosidase (Aspergillus niger) (whole) ......................... 3.75 mg (37.5 FCC GalU)

FCC (Food Chemical Codex), PU (Papain Unit), LU (Lipase Unit), DU (Dextrinizing Unit), HUT (Hemoglobin Unit on the Tyrosine Basis), SU (Serratiopeptidase Unit), CU (Cellulase Unit), ALU (Acid Lactase Unit), PC (Protease Unit), BAU (Bacterial Amylase Unit), AGU (Amyloglucosidase Unit), GaIU (Galactosidase Activity Unit).

Non-Medicinal Ingredients

Rice starch, vegetarian capsule (carbohydrate gum [cellulose], purified water, silica), vegetable grade magnesium stearate (lubricant).

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/ vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

Consult a health care practitioner if symptoms persist or worsen. Consult a health care practitioner prior to use if you have diabetes, a gastrointestinal lesion, ulcer, are taking an anticoagulant, blood thinner, anti-inflammatory, antibiotic, or are having surgery, are pregnant or breastfeeding, or have allergy to latex or fruits (avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, tomato). Headaches, heartburn, bloating, hypersensitivity/allergy, nausea, vomiting, diarrhea, and abdominal pain/epigastric pain have been known to occur, in which case discontinue use. Keep out of reach of children.

Drug Interactions

No known.

  1. Mulvihill EE, Drucker DJ. Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors. Endocr Rev. 2014 Dec;35(6):992-1019. doi:10.1210/er.2014-1035.
  2. Nongonierma AB, FitzGerald RJ. Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chem. 2014 Feb 15;145:845-52. doi:10.1016/j. foodchem.2013.08.097.
  3. Lambeir AM, Durinx C, Scharpé S, De Meester I. Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci. 2003 Jun;40(3):209-94.
  4. Hausch F, Shan L, Santiago NA, et al. Intestinal digestive resistance of immunodominant gliadin peptides. Am J Physiol Gastrointest Liver Physiol. 2002 Oct;283(4):G996-G1003.
  5. Detel D, Persic M, Varljen J. Serum and intestinal dipeptidyl peptidase IV (DPP IV/CD26) activity in children with celiac disease. J Pediatr Gastroenterol Nutr. 2007 Jul;45(1):65-70.
  6. Cerf-Bensussan N, Matysiak-Budnik T, Cellier C, Heyman M. Oral proteases: a new approach to managing coeliac disease. Gut. 2007 Feb;56(2):157-60. Epub 2006 Sep 1.