CoQ10 400 mg

CoQ10 400 mg

100% Natural

30 Softgels ( SKU: 9314, NPN: 80028342 )

Benefits

  • Identical to the form produced by the human body for high bioavailability
  • Improves many varied health conditions, including cardiovascular disease, cellular decomposition and oxidative stress
  • Higher dosage of 400 mg reduces the need of taking multiple pills during the day and keeps pace with the research
  • Free of contamination by undesirable residue or microorganisms, including bacteria or yeast
  • In a base of natural rice bran oil and vitamin E to ensure a stabilized and highly absorbable form of CoQ10

Feature Summary

The majority of the clinical uses for CoQ10 are founded upon its role as an antioxidant,and its role in mitochondrial bioenergetics. It is a coenzyme for numerous reactionsinvolved in cellular respiration, and is required for the efficient formation of adenosinetriphosphate (ATP), the cellular currency which drives the majority of enzymatic reactions.1,2 It inhibits peroxidation of cell membrane lipids as well as circulating lipoproteins.3,4 CoQ10supports cardiac tissues by improving endothelial function and by having a direct antiatherogeniceffect, which results in lower blood pressure and improved ventricularcontractility.5,6

High dose CoQ10, ranging up to 2,400 mg per day, has been used primarily forneurodegenerative diseases such as Parkinson’s and Huntington’s disease, thoughelevated doses have also been used in patients with severe cardiovascular disease oradvanced breast cancer.7,8,9 Clinical trials have shown benefit for a wide range ofcardiovascular conditions, including congestive heart failure, hypertension, and preventionof myocardial infarction.10 It also had clinical benefits for a number of other conditions,including migraine, periodontal disease, gingivitis, male infertility, and statin-inducedmyopathy.11,12

Medicinal Ingredients

Serving Size: 1 Softgel
Servings per Container: 30

Each Softgel Contains:
Coenzyme Q10 (Microorganism)..........................................400 mg

Non-Medicinal Ingredients

Rice bran oil, softgel (gelatin, glycerin, purified water, carob), natural vitamin E.

Allergens:

Contains no artificial preservatives, colour or sweeteners and no corn, dairy, starch, soy or wheat. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

While no specific contraindication exists or is predicted, data is lacking for use during pregnancy, lactation and in children, and the dosage may need to be reduced for those less than 18.

Drug Interactions

Although very little evidence supports this interaction, CoQ10 resembles vitamin K structurally, and a potentialinteraction is possible for those taking the anticoagulant Coumadin. Close monitoring of the INR is recommended with CoQ10introduction in these patients. No other negative drug interactions are known for CoQ10, though a number of medications arethought to interfere with CoQ10 synthesis or function in the body, including statin or blood pressure medications, tricyclic antidepressants,and oral hypoglycemic agents.14

  1. Potgieter M, Pretorius E, Pepper MS, et al. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. Nutr Rev. 2013 Mar;71(3):180-8.
  2. Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Nutrition. 2010 Mar;26(3):250-4. doi: 10.1016/j.nut.2009.08.008.
  3. Yubero-Serrano EM, Delgado-Casado N, et al. Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q10 in elderly men and women. Age (Dordr).2011 Dec;33(4):579-90. doi:10.1007/s11357-010-9199-8.
  4. Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007 Sep;37(1):31-7.
  5. Gao L, Mao Q, Cao J, et al. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials. Atherosclerosis. 2012 Apr;221(2):311-6.doi: 10.1016/j.atherosclerosis.2011.
  6. Rosenfeldt FL, Haas SJ, Krum H, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007 Apr;21(4):297-306.
  7. Chaturvedi RK, Beal MF. Mitochondria targeted therapeutic approaches in Parkinson’s and Huntington’s diseases. Mol Cell Neurosci. 2013 Jul;55:101-14. doi: 10.1016/j.mcn.2012.11.011.
  8. Shults CW, Flint Beal M, Song D, et al. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Exp Neurol. 2004 Aug;188(2):491-4.
  9. Villalba JM, Parrado C, Santos-Gonzalez M, et al. Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations. Expert Opin Investig Drugs. 2010Apr;19(4):535-54.
  10. Molyneux SL, Florkowski CM, George PM, et al. Coenzyme Q10: an independent predictor of mortality in chronic heart failure. J Am Coll Cardiol. 2008 Oct 28;52(18):1435-41.
  11. Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care. 2005 Nov;8(6):641-6.
  12. Safarinejad MR, Safarinejad S, et al. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled,randomized study. J Urol. 2012 Aug;188(2):526-31. doi: 10.1016/j.juro.2012.03.131.
  13. Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta. 1995 May 24;1271(1):195-204.
  14. Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Physician. 2005 Sep 15;72(6):1065-70.