30 mL Liquid ( SKU: 9317, NPN: 80047935 )
- Potent physiological balance of key fat-soluble vitamins, A, D, and K, critical to bone health
- Contains vitamin K2 (MK-7), the most bioactive and long-lasting form
- MK-7 shown to increases vertebral BMD among postmenopausal women
- Provides vitamin D3, shown to be more effective than D2 in maintaining blood levels of 25-OH vitamin D17
- Optimal form of vitamin A, palmitate, bypasses impaired conversion of carotenoids (affects nearly half the population)18
- Suitable for vegetarians
Vitamin K2, D3 &A provides clinically relevant doses of the three fat-soluble vitamins essential to optimal bone health. Although needed for cardiovascular health, blood sugar regulation, immune function, and inflammation control, vitamins A, D, and K2 have complementary physiological bone-related functions, such as modulating gene expression in osteoblasts and carboxylating osteocalcin, an enzyme needed for bone formation.1 This is exemplified by a reduction in undercarboxylated osteocalcin and an increase in bone mineral density (BMD) in postmenopausal women when vitamin K is added to vitamin D supplementation.2
Vitamin D has diverse and significant functions in multiple body systems, and widespread deficiency magnifies these crucial roles.3,4 Supplementation is associated with a well-established reduction in osteoporotic fracture.5 Correcting a vitamin D deficiency is critical when supplementing with vitamin A, as vitamin A appears to promote bone health if vitamin D levels are adequate.6,7,8 Vitamin K is now recognized as being necessary not only for coagulation, but for the carboxylation of enzymes critical for both bone and blood vessel health.9-13 Indeed, meta-analysis has shown improvement in vertebral
BMD and reduction in fracture among post-menopausal women with osteoporosis, while controlled trial data shows a reduction in the age-related decline in BMD among healthy postmenopausal women.14,15 The naturally derived MK-7 form in Vitamin K2, D3 &A has a longer half-life than any other form.16
Serving Size: 0.25 ml
Servings Per Container: 120
Each Serving (0.25 ml) Contains:
Vitamin A (Palmitate).................................................... 500 IU (151 mcg RAE)
Vitamin D3 (Cholecalciferol) .......................................1000 IU (25 mcg)
Vitamin K2 (Menaquinone) (MK-7) (Natto Bean)......50 mcg
Medium chain triglycerides, organic flaxseed oil, natural vitamin E (non-GMO sunflower oil), natural vanilla flavour
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, corn, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
1 serving (0.25 ml) per day or as directed by a health care practitioner.
Consult a health care practitioner prior to use if you are taking blood thinners. Keep out of reach of children.
Vitamin K may antagonize the effect of some anticoagulant medications, and concurrent use should be medically supervised. When taken with a thiazide medication (diuretic), vitamin D may increase the risk for hypercalcemia. Also, vitamin D may improve insulin sensitivity and lower blood pressure, requiring a reduction in dosage of hypertension and/or diabetic medications. Vitamin A should not be taken with other synthetic retinoids, such as acitretin or bexarotene.
- Doyon M, Mathieu P, Moreau P. Decreased expression of -carboxylase in diabetes-associated arterial stiffness: impact on matrix Gla protein. Cardiovasc Res. 2013 Feb 1;97(2):331-8. doi: 10.1093/cvr/cvs325.
- Cockayne S, et al. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med. 2006 Jun 26;166(12):1256-61.
- Dickens AP, et al. Vitamin D, cognitive dysfunction and dementia in older adults. CNS Drugs. 2011 Aug;25(8):629-39.
- Martins D, Wolf M, Pan D, Zadshir A, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007 Jun 11;167(11):1159-65.
- Prentice RL, Pettinger MB, Jackson RD, et al. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Osteoporos Int. 2013 Feb;24(2):567- 80. doi: 10.1007/s00198-012-2224-2. Epub 2012 Dec 4.
- Caire-Juvera G, Ritenbaugh C, Wactawski-Wende J, et al. Vitamin A and retinol intakes and the risk of fractures among participants of the Women’s Health Initiative Observational Study. Am J Clin Nutr. 2009 Jan;89(1):323-30. doi: 10.3945/ajcn.2008.26451. Epub 2008 Dec 3.
- Bettoun DJ, Burris TP, Houck KA, et al. Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation. Mol Endocrinol. 2003 Nov;17(11):2320-8.
- Ribaya-Mercado JD, Blumberg JB. Vitamin A: is it a risk factor for osteoporosis and bone fracture? Nutr Rev. 2007 Oct;65(10):425-438.
- Geleijnse JM, et al. 2004. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J. Nutr. 134:3100–5.
- McCann JC, et al. Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr. 2009 Oct;90(4):889-907.
- Schurgers LJ, et al. Matrix Gla-protein: the calcification inhibitor in need of vitamin K. Thromb Haemost. 2008 Oct;100(4):593-603.
- Yamaguchi M, et al. Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF--B activation. Int J Mol Med. 2011 Jan;27(1):3-14. doi: 10.3892/ijmm.2010.562.
- Yasui T, et al. Effect of vitamin K2 treatment on carboxylation of osteocalcin in early postmenopausal women. Gynecol Endocrinol. 2006 Aug;22(8):455-9.
- Huang ZB, Wan SL, Lu YJ, Ning, et al. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015 Mar;26(3):1175-86.
- Knapen MH, Drummen NE, Smit E, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013 Sep;24(9):2499-507.
- Schurgers LJ, et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007 Apr 15;109(8):3279-83.
- Logan VF, Gray AR, Peddie MC, et al. Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25-hydroxyvitamin D status over the winter months. Br J Nutr. 2013 Mar 28;109(6):1082-8. doi: 10.1017/S0007114512002851.
- Leung WC, et al. Two common single nucleotide polymorphisms in the gene encoding beta-carotene 15,15’-monoxygenase alter beta-carotene metabolism in female volunteers. FASEB J. 2009. Apr;23(4):1041-53.