90 Vegetarian Capsules ( SKU: 9673, NPN: 80041163 )
- Provides traditional botanicals at clinical doses for menopausal symptom relief: Angelica sinensis (dong quai), Actaea racemosa (black cohosh), and Vitex agnus-castus (chasteberry)
- Includes standardized herbal extracts for consistent effects
- Includes gamma-oryzanol and the bioflavonoid hesperidin to support symptom relief and add metabolic and cardiovascular support
- Suitable for vegetarians/vegans
For many women, the transition from pre- to post-menopause can be arduous. Changing hormone levels can lead to increased risk for both heart disease and osteoporosis,1,2 while inducing uncomfortable shorter-term issues such as vasomotor symptoms (hot flushes, night sweats), insomnia, vaginal dryness, mood changes, and reduction in libido.
MenoVantage PE is a potent formulation of botanicals and nutrients at clinically relevant doses for reducing peri-menopausal symptoms. Black cohosh (Actaea racemosa) is one of the most studied botanical extracts for menopausal symptom relief. Randomized double-blinded trials have shown a reduction in climacteric symptoms without an estrogenic effect when a standardized extract is used.3-6 Chasteberry (Vitex agnus-castus) extract is well known for modulating FSH/LH levels and mitigating premenstrual symptoms, and holds promise for reducing menopausal symptoms as well, particularly difficulty sleeping.7,8 Dong Quai (Angelica sinensis) has a long history of use in traditional medicine for reducing menopausal symptoms.9
The traditional botanicals found in MenoVantage PE are complemented by gamma-oryzanol, derived from rice bran. This natural substance has been found not only to reduce menopausal symptoms in 85% of participants, but also to improve cardiovascular risk factors, including LDL-cholesterol, a concern for many perimenopausal women.10,11 Hesperidin, a citrus bioflavonoid derived from oranges, provides relief for vasomotor symptoms of menopause, as well as potent anti-inflammatory and metabolic benefits.12-14
|Each Capsule Contains:|
|Dong Quai Extract (Angelica sinensis) (root)||100 mg|
|Chasteberry Extract (Vitex agnus-castus) (fruit)||80 mg|
|Black Cohosh Extract (Actaea racemosa) (root, rhizome)||80 mg|
|(2.5% Triterpene Glycosides as 27-deoxyactein)|
|Gamma-Oryzanol (Oryza sativa) (seed bran)||75 mg|
|Hesperidin (Citrus sinensis) (fruit)||30 mg|
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
2 capsules at breakfast and 2 capsules at bedtime per day or as directed by a health care practitioner. Use for a minimum of 3 months to see beneficial effect. Consult a health care practitioner for use beyond 6 months.
Consult a health care practitioner if symptoms persist or worsen. Consult a health care practitioner prior to use if you have a family history of cancer, have a liver disorder or develop symptoms of liver trouble, if you are taking blood thinners/anticoagulants, hormone-containing medications such as progesterone preparations, oral contraceptives or hormone replacement therapy, if you are taking any prescription medications or are breastfeeding.11,12 Discontinue use and consult a health care practitioner if you experience breast pain, discomfort and/or tenderness, increased menstrual bleeding time or if menstruation is delayed or absent. Do not use if you have diarrhea, haemorrhagic diseases, hypermenorrhea/profuse menstrual flow/heavy periods, allergy/hypersensitivity to members of the Apiaceae/Umbelliferae family (anise, caraway, carrot, celery, dill parsley), or if you are pregnant. Keep out of reach of children.
Do not use if you are using anticoagulant/antiplatelet medications (warfarin; Ticlid).15 As black cohosh may interact with CYP2E1 and CYP2D6 substrates, practitioners should be aware of potential drug interactions.16 The use of vitex is contraindicated in conjunction with bromocriptine, metaclopramide, dopamine agonists and antipsychotic drugs.17
- Matthews, K. A., Meilahn, E., Kuller, L. H., et al. (1989). Menopause and risk factors for coronary heart disease. New England Journal of Medicine, 321(10), 641-6.
- Christenson, E. S., Jiang, X., Kagan, R., et al. (2012). Osteoporosis management in post-menopausal women. Minerva Ginecologica, 64(3), 181-94.
- Osmers, R., Friede, M., Liske, E., et al. (2005). Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol, 105(5 Pt 1), 1074-83.
- Fritz, H., Seely, D., McGowan, J., et al. (2014). Black cohosh and breast cancer: a systematic review. Integr Cancer Ther, 13(1), 12-29.
- Jiang, K., Jin, Y., Huang, L., et al. (2015). Black cohosh improves objective sleep in postmenopausal women with sleep disturbance. Climacteric, 18(4), 559-67.
- Beer, A. M., Osmers, R., Schnitker, J., et al. (2013). Efficacy of black cohosh (Cimicifuga racemosa) medicines for treatment of menopausal symptoms - comments on major statements of the Cochrane Collaboration report 2012 “black cohosh (Cimicifuga spp.) for menopausal symptoms (review).” Gynecol Endocrino, 29(12), 1022-5.
- van Die, M. D., Burger, H. G., Teede, H. J et al. (2009). Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints. J Altern Complement Med, 15(8), 853-62.
- De Franciscis, P., Grauso, F., Luisi, A., et al. (2017). Adding Agnus castus and magnolia to soy isoflavones relieves sleep disturbances besides postmenopausal vasomotor symptoms-long term safety and effectiveness. Nutrients, 9(2), 129.
- Chen, J. Y., Wang, Y. H., Hidajah, A. C., et al. (2019). A population-based case-control study on the association of Angelica sinensis exposure with risk of breast cancer. J Tradit Complement Med, 10(5), 454-59.
- Bumrungpert, A., Chongsuwat, R., Phosat, C., et al. (2019). Rice bran oil containing gamma-oryzanol improves lipid profiles and antioxidant status in hyperlipidemic subjects: a randomized double-blind controlled trial. J Altern Complement Med, 25(3), 353-58.
- Ishihara, M. (1984). Effect of gamma-oryzanol on serum lipid peroxide level and clinical symptoms of patients with climacteric disturbances. Asia Oceania J Obstet Gynaeco, 10(3), 317-23.
- Cheraghpour, M., Imani, H., Ommi, S., et al. (2019). Hesperidin improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled, double-blind clinical trial. Phytother Res, 33(8), 2118-25.
- Homayouni, F., Haidari, F., Hedayati, M., et al. (2018). Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. PhytotherRes, 32(6), 1073-9.
- Philp, H. A. (2003). Hot flashes&%8212;a review of the literature on alternative and complementary treatment approaches. Altern Med Rev, 8(3), 284-302.
- Gurley, B. J., Gardner, S. F., Hubbard, M. A., et al. (2005). In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther, 77(5), 415-26.
- Shi, S., &Klotz, U. (2012). Drug interactions with herbal medicines. Clin Pharmacokine, 51(2), 77-104.
- Dugoua, J. J., Seely, D., Perri, D., et al. (2008). Safety and efficacy of chastetree (Vitex agnus-castus) during pregnancy and lactation. Can J Clin Pharmacol, 15, e74-9.