5-MTHF & B12

5-MTHF & B12

Biologically Active Folic Acid

1000 mcg

60 Sublingual Tablets ( SKU: 9426, NPN: 80072239 )

Benefits

  • Provides clinically effective dose of the most active and bioavailableform of folate, which bypasses a common bottleneck (MTHFR) in the conversion of folate to its active form
  • Each sublingual tablet also provides 50 mcg methylcobalamin, the primary circulating and biologically active form of vitamin B12
  • Sublingual tablets are suitable for vegetarians, and allow for easy dosing
  • In a base of active plant extracts, including many organic vegetables, and other bioactive plant compounds, including Theracurmin® curcumin

Feature Summary

5-MTHF &B12 provides the most biologically active forms of these two complementary B vitamins. (6S)-5-Methyltetrahydrofolate acid (MTHF) is the active form of folate at the cellular level, the form found in circulation and the only to cross the blood brain barrier, and it may be the optimal form for preventing neural tube defects.1 It does not need to be converted to an active form by the enzyme methylene tetrahydrofolate reductase (MTHFR), known to have common single-nucleotide polymorphisms that impair enzymatic activity by as much as 70%.2 Furthermore, quatrefolic acid administration has been associated with higher peak (6S)-5-MTHF levels than both folic acid and calcium 5-MTHF, with higher plasma folate levels even in those with high functioning MTHFR polymorphisms.3,4

While (6S)-5-Methyltetrahydrofolate acid does not mask a B12 deficiency as folic acid supplementation alone may, these two vitamins have complementary roles in methylation pathways that warrant combined use. Methylcobalamin is the principle circulating form of B12, and is a direct cofactor for B12-dependent enzymes. It has direct biological activity, in contrast to cyanocobalamin which is synthetically derived. When combined with other B vitamins, B12 has been shown to reduce the risk of cerebrovascular disease, depression, macular degeneration, migraine disability and hyperhomocysteinemia, with effectiveness sometimes modulated by MTHFR status.5-9

Medicinal Ingredients

Each Sublingual Tablet Contains:
Folate (from (6S)-5-Methyltetrahydrofolic Acid (MTHF),
Glucosamine Salt, Quatrefolic®) 1000 mcg
Vitamin B12 (Methylcobalamin) 50 mcg

Non-Medicinal Ingredients

Lactose, microcrystalline cellulose, croscarmellose sodium, *BioPlant ExtractsTM, vegetable grade magnesium stearate (lubricant).

*Organic kale, organic alfalfa, organic cilantro leaf, organic parsley, caperberry, sprouted garlic, organic artichoke, organic black radish, organic dandelion, barley grass, pepper, organic celery seed, organic beetroot, organic tomato, wasabi rhizome (Wasabia japonica), sprouted broccoli, organic upland cress, daikon, red radish, organic cauliflower, organic cabbage, organic arugula, organic watercress leaf, grape, pomegranate, strawberry, organic blueberry, raspberry, bilberry, organic Indian gooseberry, schizandra berry, red orange, organic açai berry, Theracurmin® curcumin, organic decaffeinated green tea extract, organic ginger rhizome, organic echinacea, organic oregano, organic peppermint, organic spearmint, organic spirulina, organic chlorella, red algae,blue green algae, kelp.

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish,shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians.

Drug Interactions

Although several classes of drugs, such as aminoglycosides, anticonvulsants, bile acid sequestrants, and proton pump inhibitors, antihyperglycemic medications (Metformin), acne therapy (isotretinoin) are known to either interfere with B12 absorption or function, there are no known negative interactions caused by B12 supplementation with any medications.10-13 Metformin has been shown to deplete B12 and folate, and supplementation with B12 only in diabetics may be preferable.14

  1. Obeid R, Holzgreve W, Pietrzik K. Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects? J Perinat Med. 2013 Sep 1;41(5):469-83.
  2. Cortese C, Motti C. MTHFR gene polymorphism, homocysteine and cardiovascular disease. Public Health Nutr. 2001 Apr;4(2B):493-7.
  3. Miraglia N, Agostinetto M, Bianchi D, Valoti E. Enhanced oral bioavailability of a novel folate salt: comparison with folic acid and a calcium folate salt in a pharmacokinetic study in rats. Minerva Ginecol. 2016 Apr;68(2):99-105.
  4. Prinz-Langenohl R, Brämswig S, Tobolski O, et al. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol. 2009 Dec;158(8):2014-21.
  5. Ji Y, Tan S, Xu Y, Chandra A, et al. Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: a meta-analysis. Neurology. 2013 Oct 8;81(15):1298-307.
  6. Almeida OP, Marsh K, Alfonso H, et al. B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trial. Ann Neurol. 2010 Oct;68(4):503-10.
  7. Lea R, Colson N, Quinlan S, et al. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009 Jun;19(6):422-8.
  8. Bjelland I, Tell GS, Vollset SE,et al. Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Arch Gen Psychiatry. 2003 Jun;60(6):618-26.
  9. Christen WG, Glynn RJ, Chew EY, et al. Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women’s Antioxidant and Folic Acid Cardiovascular Study. Arch Intern Med. 2009 Feb 23;169(4):335-41
  10. McColl KE. Effect of proton pump inhibitors on vitamins and iron. Am J Gastroenterol. 2009 Mar;104 Suppl 2:S5-9.
  11. Aslan K, Bozdemir H, Unsal C, Güvenc B. The effect of antiepileptic drugs on vitamin B12 metabolism. Int J Lab Hematol.2008 Feb;30(1):26-35.
  12. Markkanen T, Salmi HA, Sotaniemi E. Effect of neomycin treatment on the vitamin B12 content of human serum and urine. Z Vitam Horm Fermentforsch.1965;14(1):66-71.
  13. Karadag AS, Tutal E, Ertugrul DT, Akin KO. Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: non-controlled study. Int J Dermatol. 2011 Dec;50(12):1564-9.
  14. Xu L, Huang Z, He X, et al. Adverse effect of metformin therapy on serum vitamin B12 and folate: Short-term treatment causes disadvantages? Med Hypotheses. 2013 Aug;81(2):149-51.