90 Chewable Tablets Tropical Breeze ( SKU: 9281U )
- Helps support a restful, relaxed state necessary to maintain normal sleep patterns*
- Helps maintain sleep quality and quantity* Helps maintain healthy rising times without grogginess*
- Offers Suntheanine®, produced via a patented enzymatic process resulting in pure L-isomer theanine
- Tropical fruit-flavored chewable tablets
L-theanine, 5-hydroxytryptophan (5-HTP), and melatonin may help support relaxation and maintain sleep quality and quantity.* L-theanine is an amino acid found almost exclusively in tea,1 and may help support the central nervous system function.* L-theanine may also help maintain levels of neurotransmitters dopamine,2 gamma-aminobutyric acid (GABA),3,4 serotonin,5,6 norepinephrine,6 and glutamate7,8 already within the normal range.* Balanced neurotransmitters help support alpha brain wave activity, indicative of a state of wakeful relaxation, which may help maintain performance under stress, support learning and concentration, and maintain a calm mood.*1,9
5-HTP is the intermediary between L-tryptophan and serotonin, a key neurotransmitter associated with sleep, mood, and calm.*10,11,12 5-HTP bypasses the rate-limiting enzyme tryptophan hydroxylase, which normally limits the conversion of tryptophan to serotonin.13
Melatonin is also closely related and is formed by converting serotonin in the pineal gland when in low light conditions. Melatonin may help support biological rhythms, including the circadian rhythm, helping maintain healthy sleep cycles without impairing daytime psychomotor performance*14,15,16
Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.
Chew 2 tablets 30-45 minutes before bedtime or as directed by a health care professional.
Discontinue use if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain, or if you experience skin changes. Do not use if you are taking blood pressure, immunosuppressive, sedative/hypnotic medication, or if you are pregnant, breastfeeding, or have scleroderma. Some people may experience drowsiness. Do not drive or operate heavy machinery for 5 hours after using this product. Exercise caution if involved in activities requiring mental alertness.
L-theanine may alter blood pressure levels in some individuals, and concomitant use with antihypertensive drugs may potentiate their effect.17
- Juneja, L.R., Chu, D.C., Okubo, T., et al. (1999). L-Theanine – a unique amino acid of green tea and its relaxation effect in humans. Trends in Food Science & Technology, 10(2), 199-204.
- Yokogoshi, H., Kobayashi, M., Mochizuki, M., et al. (1998). Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochem Res, 23(5), 667-73.
- Kimura, R., & Murata, T. (1971). Inﬂuence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine. Chem Pharm Bull, (Tokyo), 19(6), 1257-61.
- Alternative Medicine Review. Gamma-Aminobutyric Acid (GABA), Monograph. (2007). Altern Med Rev, 12(3), 274-9.
- Yokogoshi, H., Mochizuki, M., Saitoh, K. (1998). Theanine-induced reduction of brain serotonin concentration in rats. Biosci Biotechnol Biochem, 62(4), 816-7.
- Kimura, R., & Murata, T. (1986). Effect of theanine on norepinephrine and serotonin levels in rat brain. Chem Pharm Bull (Tokyo), 34(7), 3053-7.
- Kakuda T. (2002). Neuroprotective effects of green tea components theanine and catechins. Biol Pharm Bull, 25(12), 1513-8.
- Kimura, K., Ozeki, M., Juneja, L.R., et al. (2007). L-theanine reduces psychological and physiological stress responses. Biol Psychol, 74(1), 39-45.
- Nobre, A.C, Rao, A., Owen, G.N. (2008). L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr, 17 Suppl, 167-8.
- Birdsall, T.C. (1998). 5-Hydroxytryptophan: a clinically effective serotonin precursor. Altern Med Rev, 3(4), 271-80.
- Wyatt, R.J., Zarcone, V., Engelman, K., et al. Effects of 5-hydroxytryptophan on the sleep of normal human subjects. Electroencephalogr Clin Neurophysiol, 30(6), 505-9.
- Soulairac, A., & Lambinet, H. (1998). Clinical studies of the effect of the serotonin precursor, L-5-Hydroxytryptophan, on sleep disorders. Schweiz Rundsch Med Prax, 77(34A), 19-23.
- Shaw, K., Turner, J., , Del Mar, C. (2002). Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev, (1), CD003198.
- Kunz, D., Mahlberg, R., Muller, C., et al. (2004). Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. J Clin Endocrinol Metab, 89(1), 128-34.
- Wade, A.G., Ford, I., Crawford, G., et al. (2007). Efﬁcacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next day alertness outcomes. Curr Med Res Opin, 23(10), 2597-605.
- Wade, A.G., Ford, I., Crawford, G., et al. (2010). Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efﬁcacy and safety. BMC Med, 8, 51.
- Yokogoshi, H., & Kobayashi, M. (1998). Hypotensive effect of gamma-glutamylmethylamide in spontaneously hypertensive rats. Life Sci, 62(12), 1065-8.