R-Alpha-Lipoic Acid

R-Alpha-Lipoic Acid

High Absorption and Enhanced Stability

100 mg

60 Vegetarian Capsules ( SKU: 9274U )


  • R-Alpha-Lipoic Acid includes only the naturally occurring R-isomer, the only form utilized by mitochondrial enzymes, and the only one synthesized in humans
  • R-isomer has greater biological activity than the racemic mixture often used in supplements, which is a combination of the R- and S- isomers
  • R-isomer supplementation results in higher total plasma levels, as well as a shorter time to reach maximum levels in older individuals compared to the racemic mixture
  • ALA is involved in the body’s antioxidant processes
  • Supports glutathione synthesis and helps maintain healthy mitochondrial function
  • Suitable for vegetarians/vegans

Feature Summary

Alpha-lipoic acid (ALA) has antioxidant activity, helps clear cellular debris normally produced by the body, may support healthy neurological function, and helps maintain healthy mitochondrial function. The R-isomer of ALA is a cofactor for mitochondrial enzymes and a substrate for glutathione reductase; it participates in the citric acid cycle and ATP production and recycles other antioxidants, including vitamins C, E, CoQ10, and glutathione.1 R-Alpha-Lipoic Acid includes only the R-isomer, which increased plasma levels nearly 1.5 times higher in older populations than the commonly used racemic mixture (combined R- and S- isomers).2 ALA may also support wound healing when combined with hyperbaric oxygen therapy, particularly the R isomer.3,4 ALA may support blood glucose levels already within the normal range, help maintain insulin sensitivity already within the normal range, and help maintain normal peripheral neurological function.6–8

Supplement Facts:


Suggested Usage: 1 capsule 2 times per day or as directed by a health care professional.


Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, tree nuts, or GMOs. Suitable for vegetarians/vegans.


No significant contraindications.

Drug Interactions

Caution should be used with antidiabetes medications, as ALA may have additive effects. Long-term use may warrant low-dose copper and/or thiamine supplementation.

  1. Liu, J. (2008). Neurochem Res, 33(1):194-203.
  2. Keith, D.J., Butler, J.A., Bemer, B., et al. (2012). Pharmacol Res, 66(3):199-206.
  3. Alleva, R., Nasole, E., Di Donato, F., et al. (2005). Biochem Biophys Res Commun, 333(2):404-10.
  4. Nasole, E., Nicoletti, C., Yang, Z.J., et al. (2013). J Enzyme Inhib Med Chem, 29(2), 297-302.
  5. Tomassoni, D., Amenta, F., Amantini, C., et al. (2013). Int J Mol Sci, 14(3):4580-95.
  6. Kamenova, P. (2006). Hormones (Athens), 5(4), 251-8.
  7. Han, T., Bai, J., Liu, W., et al. (2012). Eur J Endocrinol, 167(4):465-71.
  8. Tang, J., Wingerchuk, D.M., Crum, B.A., et al. (2007). Neurologist, 13(3):164-7.
  9. Xiang, G., Pu, J., Yue, L., et al. (2011). Metabolism, 60(4):480-5.
  10. Koh, E.H., Lee, W.J., Lee, S.A., et al. (2011). Am J Med, 124(1):85.e1-8.
  11. Streeper, R.S., Henriksen, E.J., Jacob, S., et al. (1997). Am J Physiol, 273(1 Pt 1):E185-91.