EstroVantage EM®

EstroVantage EM®

Estrogen Modulator

90 Vegetarian Capsules ( SKU: 9672U )


  • Helps maintain a healthy estrogen metabolism ratio during PMS or menopause*
  • Supports detoxifi cation of the body’s natural toxins as well as naturally produced hormones by supporting phase 1 and phase 2 liver enzymes*
  • Is a unique combination that includes a variety of herbal constituents
  • Suitable for vegetarians/vegans

Feature Summary

EstroVantage EM provides a comprehensive formula of plant-based compounds that may help support the normal metabolism of estrogen and its metabolites.* Cruciferous vegetables contain a variety of glucosinolates, which some studies have associated with maintaining healthy cellular structure and function, and supporting normal cell division most likely by causing a shift in metabolism to healthier estrogen metabolites.*1,2EstroVantage EM contains indole-3-carbinol (I3C) and its metabolite 3,3’-diindolylmethane (DIM), as well as sulforaphane from broccoli powder, all of which have been shown to support normal cellular structure and function as well a healthy estrogen profi le.*3-6

These glucosinolates and other plant compounds help support normal estrogen metabolism and organize the body’s response to cellular damage by targeting key signaling molecules, such as Nrf2 and NF-κB.7,8 Silymarin, a milk thistle extract, helps support normal cell structure and function.* In addition, it supports glucuronidation and helps maintain glutathione levels.*9-11This unique combination includes green tea polyphenols, lycopene (tomato extract), turmeric and rosemary extracts, as well as calcium D-glucarate, all of which have been shown to support healthy estrogen metabolism and normal cellular structure and function .*12-14

Supplement Facts:


Suggested Usage: 3 capsule per day taken with food or as directed by a health care professional. Consult a health care professional for use beyond 12 weeks.


Contains no artificial colors, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

Drug Interactions

Do not take with warfarin.15 Consult a health care professional prior to use if taking antiplatelet medication or blood thinners.

  1. Lin, T., Zirpoli, G.R., McCann, S.E., et al. (2017). Curr Dev Nutr, 1(8), e000448.
  2. Mokbel, K., & Mokbel, K. (2019). In Vivo, 33(4), 983-97.
  3. Zhang, N.Q., Ho, S.C., Mo, X.F., et al. (2018). Br J Nutr, 119(8), 957-64.
  4. Thomson, C.A., Chow, H.H.S., Wertheim, B.C., et al. (2017). Breast Cancer Res Treat, 165(1), 97-107.
  5. Ramirez, M.C., & Singletary, K. (2009). J Nutr Biochem, 20(3), 195-201.
  6. Bradlow, H.L., Michnovicz, J.J., Halper, M., et al. (1994). Cancer Epidemiol Biomarkers Prev, 3(7), 591-5.
  7. Esteve, M. (2020). Frontiers Nutr, 7, 111.
  8. Bauman, J.E., Zang, Y., Sen, M., et al. (2016). Cancer Prev Res (Phila), 9(7), 547-57.
  9. Agarwal, R., Agarwal, C., Ichikawa, H., et al. (2006). Anticancer Res, 26(6B), 4457-98.
  10. Vargas-Mendoza, N., Madrigal-Santillán, E., Morales-Gonzalez, A., et al. (2014). World J Hepatol, 6(3), 144-9.
  11. Binienda, A., Ziolkowska, S., Pluciennik, E. (2020). Anticancer Agents Med Chem, 20(15), 1787-96.
  12. King-Batoon, A., Leszczynska, J. M., Klein, C. B. (2008). Environ Mol Mutagen, 49(1), 36-45.
  13. Dwivedi, C., Heck, W.J., Downie, A.A., et al. (1990). Biochem Med and Metab Biol, 43(2), 83-92.
  14. McGrowder, D.A., Miller, F.G., Nwokocha, C.R., et al. (2020). Medicines (Basel), 7(8), 47.
  15. Brantley, S.J., Oberlies, N.H., Kroll, D.J., et al. (2010). J Pharmacol Exp Ther, 332(3), 1081-7.