EMIQ®

EMIQ®

Activated Quercetin

50 mg

60 Vegetarian Capsules ( SKU: 9411U )

Benefits

  • Highly absorbable form of quercetin*
  • Offers 40 times greater absorption than regular quercetin*
  • Includes 167 mg of enzymatically modified isoquercitin (EMIQ), yielding 50 mg of quercetin, as well as 50 mg of vitamin C per capsule
  • Prepared using an enzyme process that attaches polysaccharides to convert quercetin into a soluble form 
  • Suitable for vegetarians and vegans

Feature Summary

Quercetin, a dietary flavonol known to be one of the most significant plant-derived antioxidants,has multiple biological actions, with preclinical studies showing that it helps clear cellular debris naturally produced by the body and supports healthy cardiovascular and respiratory function.*1 

The limiting factor in quercetin’s supportive function appears to be its poor bioavailability. Enzymatically modified isoquercitrin (EMIQ) is a mixture of quercetin monoglucoside and its alpha-oligoglucosides that has been shown to have significantly greater bioavailability than other available forms. In animals, EMIQ was shown to produce a 40-fold increase in C(max) (peak plasma concentration) and an 18-fold increase in the area under the curve compared to quercetin.2 In humans, EMIQ supplementation increased plasma concentrations to a significantly greater degree than other forms, including the aglycone and isoquercitrin (Q3G) forms.3 

Quercetin helps maintain histamine levels already within the normal range.*10 Studies have shown EMIQ to be considerably more bioavailable than regular quercetin. Two trials found that EMIQ may help with seasonal support of upper respiratory health and outdoor nose and eye health.*11,12 In a recent crossover trial, EMIQ was found to support healthy endothelial function and helped maintain healthy cardiovascular function.*13 Healthy American football players supplementing with whey protein had greater gains in lower limb muscle mass and antioxidant protection when consuming 42 mg EMIQ per day compared to whey alone.*14

Supplement Facts:

Allergens:

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

Dosage:

Suggested Usage: 1 capsule 1–2 times per day or as directed by a health care professional

Contraindications

No specific contraindications, although safety has not been established during pregnancy or lactation. Patients with impaired renal function should also use with caution.

Drug Interactions

No specific drug interactions, although theoretically, drugs metabolized by CYP3A4 and/or P-glycoprotein (Pgp) could have altered pharmacokinetics/bioavailability.8,9

  1. Erdman, J.W. Jr., Balentine, D., Arab, L., et al. (2007). Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31–June 1, 2005, Washington, DC. J Nutr, 137(3 Suppl 1), 718S-37S.
  2. Makino, T., Shimizu, R., Kanemaru, M., et al. (2009). Biol Pharm Bull, 32(12), 2034-40.
  3. Murota, K., Matsuda, N., Kashino, Y., et al. (2010). Arch Biochem Biophys, 501(1), 91-7.
  4. Bondonno, N.P., Bondonno, C.P., Ward, N.C., et al. (2020). Br J Nutr, 123(2), 182-9.
  5. Omi, N., Shiba, H., Nishimura, E., et al. (2019). J Int Soc Sports Nutr, 16(1), 39.
  6. Hirano, T., Kawai, M., Arimitsu, J., et al. (2009). Allergol Int, 58(3), 373-82.
  7. Kawai, M., Hirano, T., Arimitsu, J., et al. (2009). Int Arch Allergy Immunol, 149(4), 359-68.
  8. Hsiu, S.L., Hou, Y.C., Wang, Y.H., et al. (2002). Life Sci, 72(3), 227-35. 
  9. Valentová, K., Vrba, J., Bancířová, M., et al. (2014). Food Chem Toxicol, 68, 267-82.
  10. Mlcek, J., Jurikova, T., Skrovankova, S., et al. (2016). Molecules, 21(5), 623.
  11. Hirano, T., Kawai, M., Arimitsu, J., et al. (2009). Allergol Int, 58(3), 373-82.
  12. Kawai, M., Hirano, T., Arimitsu, J., et al. (2009). Int Arch Allergy Immunol, 149(4), 359-68.
  13. Bondonno, N.P., Bondonno, C.P., Ward, N.C., et al. (2020). Br J Nutr, 123(2), 182-9.
  14. Omi, N., Shiba, H., Nishimura, E., et al. (2019). J Int Soc Sports Nutr, 16(1), 39.