400 mg

180 Chewable Tablets ( SKU: 9227U )


  • Offers 400 mg of DGL per tablet
  • Supports the stomach lining by stimulating mucus formation and secretion, offering relief for occasional stomach and digestive tract discomfort*
  • The chewable delivery system is preferred because saliva enhances the effect of DGL’s natural compounds, allowing licorice to be released in the stomach and absorbed by the gastric mucosa
  • Deglycyrrhizination prevents some of the adverse effects commonly associated with licorice consumption, such as hypertension
  • Pleasant-tasting tablets for better compliance
  • Suitable for vegetarians/vegans

Feature Summary

Deglycyrrhizinated licorice, or DGL, has been used for decades to help with occasional stomach. and digestive tract discomfort and support a healthy stomach lining.*1  Licorice has many triterpenoids and hundreds of flavonoids that have been shown to inhibit specific enzymes including both cyclooxygenase-2 (COX-2)  and 5-lipoxygenase (5-LOX). These enzymes increase the production of several compounds, including IL-6, prostaglandin E2, thromboxane B2, and leukotriene B4. Consequently, inhibition helps organize the body’s response to cellular damage.*2  Importantly, this inhibition is not primarily due to glycyrrhizic acid, the component of licorice that has been removed from DGL, and that is associated with mineralocorticoid excess and hypertension.3  

Licorice has multiple useful compounds that help clear normal cellular debris and help support healthy immune homeostasis, including glabridin and at least seven licochalcones.* These compounds may help organize the body’s response to cellular damage and are involved in antioxidant processes.*4-6 Licorice extracts have been shown to support the normal integrity of the gastric mucosa via multiple mechanisms.*6,7  The use of chewable tablets appears necessary for DGL’s efficacy, as it allows for distribution and absorption by the gastric mucosa.6

Supplement Facts:


Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.


Suggested Usage: Chew 1 tablet 20 minutes before each meal or as directed by a health care professional. Consult a health care professional for use beyond 16 weeks.

Drug Interactions

No known drug interactions. Licorice influences the activity of several cytochrome enzymes and reduces warfarin activity in animal models, likely due to glycyrrhizic acid activity. DGL use should be carefully monitored in these patients. 

1. Turpie, A G., Runcie, J., Thomson, T.J. (1969). Clinical trial of deglydyrrhizinized liquorice in gastric ulcer. Gut, 10(4), 299-302.

2. Yang, R., Wang, L.Q., Yuan, B.C., et al. (2015). The pharmacological activities of licorice. Planta Med, 81(18), 1654-69.

3. Chandrasekaran, C.V., Deepak, H.B., Thiyagarajan, P., et al. (2011). Dual inhibitory effect of Glycyrrhiza glabra (GutGard) on  COX and LOX products. Phytomedicine, 18(4), 278-84.

4. Yehuda, I., Madar, Z., Szuchman-Sapir, A., et al. (2011). Glabridin, a phytoestrogen from licorice root, up-regulates manganese superoxide dismutase, catalase and paraoxonase 2 under glucose stress. Phytother Res, 25(5), 659-67.

5. Maria Pia, G.D., Sara, F., Mario, F., et al. (2019). Biological effects of licochalcones. Mini Rev Med Chem, 19(8), 647-56.

6. Ahn, S.J., Cho, E.J., Kim, H.J., et al. (2012). The antimicrobial effects of deglycyrrhizinated licorice root extract on Streptococcus mutans UA159 in both planktonic and biofilm cultures. Anaerobe, 18(6), 590-6.

7. Maria Pia, G.D., Sara, F., Mario, F., et al. (2019). Biological effects of licochalcones. Mini Rev Med Chem, 19(8), 647-56.