Biologically Active Form of B12

1000 mcg

60 Lozenges ( SKU: 9420U )


  • Methylcobalamin is the form of vitamin B12 that is active in the central nervous system*
  • Superior bioavailability* ¹
  • Supports healthy homocysteine levels already within the normal range, in support of cardiovascular health*
  • Lozenges dissolve quickly in the mouth and are easy to take

Feature Summary

Vitamin B12 is the cofactor in enzymatic reactions with diverse physiological functions. Methylcobalamin, the principal circulating form of B12 and the one transported into peripheral tissues, has been shown to support normal homocysteine levels, helps organize the body’s response to cellular damage,  maintain cardiovascular health, and support healthy neuronal function.*5–8

Cobalamin is also required to remove the methyl group from methyltetrahydrofolate and generate tetrahydrofolate, a necessary step in DNA synthesis. Consequently, B12 is needed for the healthy growth, function, and repair of all cells, including red blood cells.*9  Vitamin B12 supplementation is of particular importance to vegetarians and those suffering from vitamin B12 deficiency.* B12 in lozenge form, at an amount of 1000 mcg per day, can help maintain B12 levels already within the normal range equivalently to other routes of administration.*10–13

Supplement Facts:


Suggested Usage: 1 lozenge per day or as directed by a health care professional. Chew or hold in mouth until dissolved.


Contains no artificial colors, preservatives, or sweeteners; no starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians.


Supplemental folic acid may mask a B12 deficiency, which should be ruled out. Folic acid, as well as increased potassium intake, is recommended with B12 therapy.

Drug Interactions

Although several classes of drugs, such as aminoglycosides, anticonvulsants, bile acid sequestrants, and proton pump inhibitors, antihyperglycemic medications (Metformin), acne therapy (isotretinoin) are known to interfere with B12 absorption or function, there are no known negative interactions caused by B12 supplementation with any medications.15-21

  1. [No authors listed]. (1998). Methylcobalamin. Altern Med Rev, 3(6), 461-3.
  2. Guéant, J.L.1, Caillerez-Fofou, M., Battaglia-Hsu, S., et al. (2013). Biochimie, 95(5), 1033-40.
  3. Calderón-Ospina, C.A., Nava-Mesa, M.O. (2020). CNS Neurosci Ther, 26(1), 5-13.
  4. Austin, R.C., Lentz, S.R., Werstuck, G.H. (2004). Cell Death Differ, 11(1), S56-64.
  5. Miranda-Massari, J.R., Gonzalez, M.J., Jimenez, F.J., et al. (2011). Curr Clin Pharmacol, 6(4), 260-73.
  6. Yuan, M., Wang, B., Tan, S. (2018). Rev Assoc Med Bras (1992), 64(5), 428-32.
  7. Jiang, D.Q., Zhao, S.H., Li, M.X., et al. (2018). Medicine (Baltimore), 97(44), e13020.
  8. Buesing, S., Costa, M., Schilling, J.M., et al. (2019). Pain Physician, 22(1), E45-E52.
  9. Parry, T.E. (1987). Baillieres Clin Haematol, 1(2), 315-53.
  10. Kim, H.I., Hyung, W.J., Song, K.J., et al. (2011). Ann Surg Oncol, 18(13), 3711-7.
  11. Schijns, W., Homan, J., van der Meer, L., et al. (2018). Am J Clin Nutr, 108(1), :6-12.
  12. Bolaman, Z., Kadikoylu, G., Yukselen, V., et al. (2003). Clin Ther, 25(12), 3124-34.
  13. Bensky, M.J., Ayalon-Dangur, I., Ayalon-Dangur, R., et al. (2019). Drug Deliv Transl Res, 9(3), 625-30
  14. Paul, C., Brady, D.M. (2017). Integr Med (Encinitas), 16(1), 42-9.
  15. McColl, K.E. (2009). Am J Gastroenterol, 104(l 2), S5-9.
  16. Aslan, K., Bozdemir, H., Unsal, C., et al. (2008). Int J Lab Hematol, 30(1), 26-35.
  17. de Jager, J., Kooy, A., Lehert, P., et al. (2010). BMJ, 340, c2181.
  18. Aroda, V.R., Edelstein, S.L., Goldberg, R.B., et al. (2016). J Clin Endocrinol Metab, 101(4), 1754-61.
  19. Markkanen, T., Salmi, H.A., Sotaniemi, E. (1965). Z Vitam Horm Fermentforsch, 14(1), 66-71.
  20. Karadag, A.S., Tutal, E., Ertugrul, D.T., et al. (2011).  Int J Dermatol, 50(12), 1564-9.
  21. Dierkes, J., Westphal, S., Kunstmann, S., et al. (2001). Atherosclerosis, 158(1), 161-4.