Ultimate Prostate Support

Ultimate Prostate Support

Healthy prostate support

60 ( SKU: 9258, NPN: 80028703 )

Benefits

  • Provides a combination of botanicals and nutrients with broad-based support for prostate health
  • Botanicals have multiple mechanisms of action to limit inflammation and hypertrophy of the prostate
  • Helps relieve the urological symptoms associated with mild-to-moderate benign prostatic hyperplasia (BPH) (e.g., weak urine flow, incomplete voiding, frequent daytime and nighttime urination)
  • Standardized ingredients to ensure potency
  • Softgel allows for easy use, with clinical-based doses

Feature Summary

Ultimate Prostate Support provides a unique and comprehensive blend of botanicals and nutrients designed to support prostate health through complementary mechanisms. Saw palmetto, perhaps the most well-researched botanical, has been shown to bind to α1-adrenergic receptors, inhibit 5α-reductase activity, and have an anti-inflammatory effect in the prostate.1,2 Several meta-analyses of randomized controlled trials indicate it provides similar symptom relief to standard therapies for benign prostatic hypertrophy (BPH) or chronic prostatitis without the adverse effects on sexual function that may accompany standard treatment.3-7

Phytosterols also provide anti-inflammatory and antiproliferative effects. They have been shown to relieve symptoms of BPH when used alone and to enhance saw palmetto’s effects when used together.8-11 Nettle has anti-inflammatory and antioxidant properties, and also inhibits androgen activity in the prostate, with multiple clinical trials supporting its use.2,12,13 Turmeric has potent anti-inflammatory activity and has been shown to improve prostate-related symptoms as part of combination therapies.14-16 Rye flower pollen extract and Pygeum africanum have anti-inflammatory and antiproliferative effects on the prostate, with clinical trial data indicating they provide relief from prostate-related symptoms (often as part of combination therapies).17-21 Tomato extract provides numerous plant-based antioxidants, including lycopene, which have been shown to have anti-inflammatory, antioxidant, and antiproliferative effects, as well as improve symptoms associated with prostatic hypertrophy.2,22

Medicinal Ingredients

Each Softgel Contains:
Saw Palmetto Extract (Serenoa repens) (fruit)
  (Standardized to 85–95% fatty acids) 		160 mg
Phytosterols (plant)
  (80% combined beta-sitosterol, campesterol, and stigmasterol) 		100 mg
Nettle Extract 10:1 (Urtica dioica) (root) 75 mg
Turmeric Extract (Curcuma longa) (root)
  (Standardized to 95% curcuminoids) 		25 mg
Rye Flower Pollen Extract 20:1
  (Secale cereale) (pollen) 		25 mg
Pygeum africanum Extract (bark) 25 mg
Tomato Extract (Lycopersicon esculentum) (fruit)
  (Standardized to 6% lycopene) 		1 mg

Non-Medicinal Ingredients

Softgel (gelatin, glycerin, purified water, carob), soybean oil, yellow beeswax, lecithin.

Dosage:

Recommended Adult Dose: 1 softgel 2 times per day or as directed by a health care practitioner. Take with food to minimize gastric disturbance.

Warnings:

Consult a health care practitioner if you are taking anticoagulant or hormone medications, if you experience gastrointestinal discomfort, or if symptoms persist or worsen. Consult a health care practitioner prior to use to exclude a diagnosis of prostate cancer. Consult a health care practitioner prior to use if you have gallstones, a bile duct obstruction, stomach ulcers, or excess stomach acid. Not intended for use by women. Keep out of reach of children.

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, egg, fish, shellfish, salt, tree nuts, or GMOs. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

No absolute contraindications are established; review cautions listed.

Drug Interactions

No specific drug interactions exist, though a theoretical interaction between turmeric and anti-platelet medications suggests caution if used concomitantly.23,24

  1. Kwon, Y. (2019). Use of saw palmetto (Serenoa repens) extract for benign prostatic hyperplasia. Food Sci Biotechnol, 28(6), 1599-606. 
  2. Stewart, K.L., & Lephart, E.D. (2023). Overview of BPH: Symptom relief with dietary polyphenols, vitamins and phytochemicals by nutraceutical supplements with implications to the prostate microbiome. Int J Mol Sci, 24(6), 5486. 
  3. Vela-Navarrete, R., Alcaraz, A., Rodríguez-Antolín, A., et al. (2018). Efficacy and safety of a hexanic extract of Serenoa repens (Permixon®) for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH): Systematic review and meta-analysis of randomised controlled trials and observational studies. BJU Int, 122(6), 1049-65. 
  4. Cai, T., Cui, Y., Yu, S., et al. (2020). Comparison of Serenoa repens with tamsulosin in the treatment of benign prostatic hyperplasia: A systematic review and meta-analysis. Am J Mens Health, 14(2), 1557988320905407. 
  5. Zhang, K., Guo, R.Q., Chen, S.W., et al. (2021). The efficacy and safety of Serenoa repens extract for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome: A multicenter, randomized, double-blind, placebo-controlled trial. World J Urol, 39(9), 3489-95. 
  6. Nickel, J.C., Chughtai, B., De Nunzio, C., et al. (2022). Rethinking the role of saw palmetto extract for men with lower urinary tract symptoms in North America. Uro, 2(3), 137-50. 
  7. Paulis, G., Paulis, A., & Perletti, G. (2021). Serenoa repens and its effects on male sexual function. A systematic review and meta-analysis of clinical trials. Arch Ital Urol Androl, 93(4), 475-80 
  8. Bao, X., Zhang, Y., Zhang, H., et al. (2022). Molecular mechanism of β-sitosterol and its derivatives in tumor progression. Front Oncol, 12, 926975. 
  9. Paniagua-Pérez, R., Flores-Mondragón, G., Reyes-Legorreta, C., et al. (2016). Evaluation of the anti-inflammatory capacity of beta-sitosterol in rodent assays. Afr J Trad Complement Altern Med, 14(1), 123-30. 
  10. Klippel, K.F., Hiltl, D.M., & Schipp, B. (1997). A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group. Br J Urol, 80(3), 427-32. 
  11. Sudeep, H.V., Thomas, J.V., & Shyamprasad, K. (2020). A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency. BMC Urol, 20(1), 86. 
  12. Safarinejad, M.R. (2005). Urtica dioica for treatment of benign prostatic hyperplasia: A prospective, randomized, double-blind, placebo-controlled, crossover study. J Herb Pharmacother, 5(4), 1-11. 
  13. Akbar Karami, A., Sheikhsoleimani, M., Reza Memarzadeh, M., et al. (2020). Urtica dioica root extract on clinical and biochemical parameters in patients with benign prostatic hyperplasia, randomized controlled trial. Pak J Biol Sci, 23(10), 1338-44. 
  14. Cosentino, V., Militello, A., & Lauria, G. (2018). Short-term effects of a dietary supplement on lower urinary tract symptoms. J Biol Regul Homeost Agents, 32(6), 1557-63. 
  15. Ledda, A., Belcaro, G., Dugall, M., et al. (2012). Meriva®, a lecithinized curcumin delivery system, in the control of benign prostatic hyperplasia: A pilot, product evaluation registry study. Panminerva Med, 54(1 Suppl 4), 17-22. 
  16. Bagherniya, M., Askari, G., Alikiaii, B., et al. (2021). Curcumin for the treatment of prostate diseases: A systematic review of controlled clinical trials. Adv Exp Med Biol, 1291, 345-62. 
  17. Antoniou, V., Gauhar, V., Modi, S., et al. (2023). Role of phytotherapy in the management of BPH: A summary of the literature. J Clin Med, 12(5), 1899. 
  18. Preuss, H.G., Marcusen, C., Regan, J., et al. (2001). Randomized trial of a combination of natural products (cernitin, saw palmetto, B-sitosterol, vitamin E) on symptoms of benign prostatic hyperplasia (BPH). Int Urol Nephrol, 33(2), 217-25. 
  19. Chatelain, C., Autet, W., & Brackman, F. (1999). Comparison of once and twice daily dosage forms of Pygeum africanum extract in patients with benign prostatic hyperplasia: A randomized, double-blind study, with long-term open label extension. Urology, 54(3), 473-8. 
  20. Coulson, S., Rao, A., Beck, S.L., et al. (2013). A phase II randomised double-blind placebo-controlled clinical trial investigating the efficacy and safety of ProstateEZE Max: A herbal medicine preparation for the management of symptoms of benign prostatic hypertrophy. Complement Ther Med, 21(3), 172-9. 
  21. Breza, J., Dzurny, O., Borowka, A., et al. (1998). Efficacy and acceptability of tadenan (Pygeum africanum extract) in the treatment of benign prostatic hyperplasia (BPH): A multicentre trial in central Europe. Curr Med Res Opin, 14(3), 127-39. 
  22. Kutwin, P., Falkowski, P., Łowicki, R., et al. (2022). Are we sentenced to pharmacotherapy? Promising role of lycopene and vitamin A in benign urologic conditions. Nutrients, 14(4), 859. 
  23. Pagano, E., Laudato, M., Griffo, M., et al. (2014). Phytotherapy of benign prostatic hyperplasia. A minireview. Phytother Res, 28(7), 949-55. 
  24. Keihanian, F., Saeidinia, A., Bagheri, R.K., et al. (2018). Curcumin, hemostasis, thrombosis, and coagulation. J Cell Physiol, 233(6), 4497-511.