250 mg

60 Vegetarian Capsules ( SKU: 9527, NPN: 80125083 )


  • Provides 250 mg of all-natural trans-resveratrol per serving
  • Trans-resveratrol promotes cellular health and longevity, with potent antioxidant effects
  • Activates Nrf2 and SIRT1, associated with cellular protection and healthy aging effects
  • Resveratrol is extracted from red grapes grown in the Okanagan Valley of British Columbia and from Japanese knotweed
  • Suitable for vegans and vegetarians

Feature Summary

Resveratrol is a natural polyphenol found in many plants, especially grapes and peanuts. It is widely recognized as a potent antioxidant with multiple actions that promote cellular longevity and health. Resveratrol provides protection against oxidative stress both via direct antioxidant effects and by activating cellular pathways associated with antioxidant defence. This includes stimulation of the potent transcription factor, nuclear erythroid 2-related factor 2 (Nrf2), which increases the expression of multiple antioxidant enzymes associated with cardioprotective, neuroprotective, and healthy aging effects.1–3

Resveratrol also activates the sirtuin SIRT1, a protein responsible for regulating many essential cellular functions, including DNA repair, mitochondrial biogenesis, autophagy, inflammation, metabolism, and more. SIRT1 has been associated with healthspan, longevity, cardiovascular function, and reduced risk for many age-related conditions.4–6 Indeed, SIRT1 is considered a “longevity gene,” as many of the longevity benefits of calorie restriction observed in experimental studies are thought to be mediated through SIRT1 activation.7–10 Clinical trials with resveratrol have demonstrated several aging-related benefits, including increased SIRT1 levels, enhanced cognitive function, and improved cardiovascular risk factors.11–14

Extracted from the skin of red grapes grown in the Okanagan Valley of British Columbia and from Japanese knotweed, this formula provides 100% trans-resveratrol, which is more bioavailable and stable than cis-resveratrol.15,16

Medicinal Ingredients

Each Vegetarian Capsule Contains:
Trans-Resveratrol [Vitis vinifera (fruit) and Reynoutria japonica (root)] 250 mg

Non-Medicinal Ingredients

Vegetarian capsule (carbohydrate gum [cellulose], purified water), rice flour, vegetable grade magnesium stearate (lubricant), silica.


Recommended Adult Dose: 1 capsule per day or as directed by a health care practitioner.


Consult a health care practitioner prior to use if you are pregnant or breastfeeding or if you are taking prescription medications as resveratrol may alter the effectiveness of these medications. Keep out of reach of children.


Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.


No known contraindications.

Drug Interactions

Resveratrol is considered a weak inhibitor of CYP3A4/5 and CYP2E1, and may increase the plasma concentration of drugs metabolized by these enzymes, such as triazolam and carbamazepine.17–19

  1. Farkhondeh, T., Folgado, S.L., Pourbagher-Shahri, A.M., et al. (2020). The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway. Biomed Pharmacother, 127, 110234.
  2. Seyyedebrahimi, S., Khodabandehloo, H., Nasli Esfahani, E., et al. (2018). The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial. Acta Diabetol, 55(4), 341-53.
  3. Zamanian, M.Y., Parra, R.M.R., Soltani, A., et al. (2023). Targeting Nrf2 signaling pathway and oxidative stress by resveratrol for Parkinson's disease: An overview and update on new developments. Mol Biol Rep, 50(6), 5455-64.
  4. You, Y., & Liang, W. (2023). SIRT1 and SIRT6: The role in aging-related diseases. Biochim Biophys Acta Mol Basis Dis, 1869(7), 166815.
  5. Nogueiras, R., Habegger, K.M., Chaudhary, N., et al. (2012). Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism. Physiol Rev, 92(3), 1479-514.
  6. Leal, D.P., Gonçalinho, G.H.F., Tavoni, T.M., et al. (2022). The interplay of sirtuin-1, LDL-cholesterol, and HDL function: A randomized controlled trial comparing the effects of energy restriction and atorvastatin on women with premature coronary artery disease. Antioxid, 11(12), 2363.
  7. Tang, B.L. (2016). Sirt1 and the mitochondria. Mol Cells, 39(2), 87-95.
  8. Razick, D.I., Akhtar, M., Wen, J., et al. (2023). The role of sirtuin 1 (SIRT1) in neurodegeneration. Cureus, 15(6), e40463.
  9. Gonçalinho, G.H.F., Kuwabara, K.L., Faria, N.F.O., et al. (2023). Sirtuin 1 and vascular function in healthy women and men: A randomized clinical trial comparing the effects of energy restriction and resveratrol. Nutrients, 15(13), 2949.
  10. Sun, Z., Zhao, S., Suo, X., et al. (2022). Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice. BMC Neurosci, 23(1), 33.
  11. Thaung Zaw, J.J., Howe, P.R., & Wong, R.H. (2021). Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study. Clin Nutr, 40(3), 820-9.
  12. Tomé-Carneiro, J., Gonzálvez, M., Larrosa, M., et al. (2012). Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Mol Nutr Food Res, 56(5), 810-21.
  13. García-Martínez, B.I., Ruiz-Ramos, M., Pedraza-Chaverri, J., et al. (2023). Effect of resveratrol on markers of oxidative stress and sirtuin 1 in elderly adults with type 2 diabetes. Int J Mol Sci, 24(8), 7422.
  14. Batista-Jorge, G.C., Barcala-Jorge, A.S., Silveira, M.F., et al. (2020). Oral resveratrol supplementation improves metabolic syndrome features in obese patients submitted to a lifestyle-changing program. Life Sci, 256, 117962.
  15. Gambini, J., Inglés, M., Olaso, G., et al. (2015). Properties of resveratrol: In vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans. Oxid Med Cell Longev, 2015, 837042.
  16. Singh, A.P., Singh, R., Verma, S.S., et al. (2019). Health benefits of resveratrol: Evidence from clinical studies. Med Res Rev, 39(5), 1851-91.
  17. Gómez-Garduño, J., León-Rodríguez, R., Alemón-Medina, R., et al. (2022). Phytochemicals that interfere with drug metabolism and transport, modifying plasma concentration in humans and animals. Dose-Response, 20(3), 15593258221120485.
  18. Hyrsova, L., Vanduchova, A., Dusek, J., et al. (2019). Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors. Toxicol Lett, 300, 81-91.
  19. Bedada, S.K., & Neerati, P. (2016). Resveratrol pretreatment affects CYP2E1 activity of chlorzoxazone in healthy human volunteers. Phytother Res, 30(3), 463-8.