Clinical Strength

500 mg

60 Vegetarian Capsules ( SKU: 9256, NPN: 80033464 )


  • Natural Eggshell Membrane (NEM®) is clinically proven to reduce joint pain and stiffness resulting from osteoarthritis
  • Clinically shown to reduce pain and stiffness resulting from moderate-intensity aerobic exercise
  • Pain, stiffness, and flexibility shown to improve within days of use
  • NEM provides multiple joint nutrients, including glucosamine, chondroitin, and collagen type I
  • One vegetarian capsule of NEM per day is the clinically proven dose

Feature Summary

Multiple clinical trials have shown that NEM reduces joint pain and stiffness associated with osteoarthritis, and reduces joint pain and stiffness caused by moderate-intensity aerobic exercise. NEM is comprised of (shell-free) eggshell membranes, a natural source of the glycosaminoglycans found in cartilage, including dermatan sulfate and chondroitin sulfate, hexosamines such as glucosamine, as well as hyaluronic acid and collagen type I.1 In vitro and in vivo trials indicate that NEM has multiple mechanisms of action, including the inhibition of several proinflammatory cytokines associated with joint inflammation, such as interleukin-1 beta (IL-1β) and tumour necrosis factor-alpha (TNF-α).2,3

In a randomized, double-blind, placebo-controlled trial, NEM was shown to rapidly reduce pain, stiffness, and discomfort following exercise in healthy postmenopausal women. It was also shown to reduce urinary levels of C-terminal cross-linked telopeptide of type II collagen (CTX-II), a biomarker for cartilage degradation, both in healthy people and those with joint disease.4 In addition, controlled clinical trials have shown a reduction in joint pain and stiffness in individuals with knee osteoarthritis within 10 days of use. Open-label trials have shown persistent improvements in pain and flexibility for multiple joint and connective tissue disorders within one week.1,5–7

Medicinal Ingredients

Each Vegetarian Capsule Contains:
NEM® Natural Eggshell Membrane (Gallus gallus) (eggshell) 500 mg

Non-Medicinal Ingredients

Vegetarian capsule (carbohydrate gum, purified water, silica), dibasic calcium phosphate dihydrate, vegetable grade magnesium stearate (lubricant).


Recommended Adult Dose: 1 capsule per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 8 weeks.


Do not use if you have a known allergy to eggs or egg by-products. Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Consult a health care practitioner if symptoms worsen. Keep out of reach of children.


Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians.


Avoid in case of allergy to eggs or egg by-products.

Drug Interactions

No known drug interactions.

1.      Ruff, K.J., Winkler, A., Jackson, R.W., et al. (2009). Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: A randomized, multicenter, double-blind, placebo-controlled clinical study. Clin Rheumatol, 28(8), 907-14.

2.      Benson, K.F., Ruff, K.J., & Jensen, G.S. (2012). Effects of natural eggshell membrane (NEM) on cytokine production in cultures of peripheral blood mononuclear cells: Increased suppression of tumor necrosis factor-α levels after in vitro digestion. J Med Food, 15(4), 360-8.

3.      Ruff, K.J., & DeVore, D.P. (2014). Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product. Mod Res Inflamm, 3(1), 19-25.

4.      Ruff, K.J., Morrison, D., Duncan, S.A., et al. (2018). Beneficial effects of natural eggshell membrane versus placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women. Clin Interv Aging, 13, 285-95.

5.      Brunello, E., & Masini, A. (2016). NEM® brand eggshell membrane effective in the treatment of pain and stiffness associated with osteoarthritis of the knee in an Italian study population. Int J Clin Med, 7, 169-75.

6.      Ruff, K.J., DeVore, D.P., Leu, M.D., et al. (2009). Eggshell membrane: A possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies. Clin Interv Aging, 4, 235-40.

7.      Eskiyurt, N., Saridoğan, M., Senel K., et al. (2019). Efficacy and safety of natural eggshell membrane (NEM®) in patients with grade 2/3 knee osteoarthritis: A multi-center, randomized, double-blind, placebo-controlled, single-crossover clinical study. J Arthritis, 8(4), 1000285.