120 Vegetarian Capsules ( SKU: 9255, NPN: 80075249 )
- Magnesium bisglycinate form is more easily absorbed than salt forms such as magnesium oxide1
- Bisglycinate chelated form is less likely to cause laxative effects than salt forms1,2
- Vegetarian capsules provide 200 mg of elemental magnesium per capsule
- Non-GMO and suitable for vegetarians/vegans
Magnesium helps maintain proper muscle function and bone health. It also supports metabolism, the ability to derive energy from proteins, carbohydrates, and fat.3 The body’s magnesium needs can be increased by stress, an unbalanced diet, coffee and alcohol consumption4, and certain medications such as proton-pump inhibitors.5 As a result, it can be difficult to meet the body’s daily magnesium needs through diet alone.6
In a randomized, controlled trial, healthy older women were assigned to the treatment group receiving 300 mg of magnesium daily or to a control group. After 12 weeks, the treatment group had significant improvements in physical performance compared to the control group. The authors concluded that supplementation may have a role in preventing age-related physical decline.7 A double-blind, placebo-controlled trial found that supplementation with 300 mg of magnesium bisglycinate daily for four weeks decreased the frequency and intensity of pregnancy-induced leg cramps.8 Magnesium is an important factor in muscle mass and repair and has been shown to relieve muscle cramps of various causes.9 Magnesium is also an important factor for maintaining bone health. Multiple systematic reviews have found a higher intake of magnesium to be associated with both a higher bone mineral density as well as a lower risk of fracture among older adults.10,11
|Each Vegetarian Capsule Contains:|
|[Magnesium Bisglycinate Blend (magnesium bisglycinate, magnesium oxide, glycine)]|
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.
Recommended Adult Dose: 1 capsule per day or as directed by a health care practitioner.
Keep out of reach of children.
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.
None known, though medical supervision is needed for individuals with renal disease.12
When taken together, magnesium can decrease the absorption of levodopa/carbidopa13, quinolone antibiotics14, and tetracycline antibiotics15, and can increase the absorption of sulfonylureas.16 Magnesium levels may be depleted by aminoglycoside antibiotics17, amphotericin B18, cyclosporine17, digoxin19, potassium-wasting diuretics17, oral contraceptives20, foscarnet21, sodium phosphates22, tacrolimus23, and proton-pump inhibitors.5
- Schuette, S.A., Lashner, B.A., & Janghorbani, M. (1994). Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. JPEN J Parenter Enteral Nutr, 18(5), 430-5.
- Siebrecht, S. (2013). Magnesium bisglycinate as safe form for mineral supplementation in human nutrition. OM & Ernahrung, 144.
- Jahnen-Dechent, W., & Ketteler, M. (2012). Magnesium basics. Clin Kidney J, 5(1), i3-i14.
- Nechifor, M. (2018). Magnesium in addiction - A general view. Magnes Res, 31(3), 90-8.
- Janett, S., Camozzi, P., Peeters, G.G.A.M., et al. (2015). Hypomagnesemia induced by long-term treatment with proton-pump inhibitors. Gastroenterol Res Pract, 2015, 951768.
- Health Canada. (2020). Do Canadian adults meet their nutrient requirements through food intake alone? Canada.ca. Retrieved from https://www.canada.ca/en/health-canada/services/food-nutrition/food-nutrition-surveillance/health-nutrition-surveys/canadian-community-health-survey-cchs/canadian-adults-meet-their-nutrient-requirements-through-food-intake-alone-health-canada-2012.html
- Veronese, N., Berton, L., Carraro, S., et al. (2014). Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: A randomized controlled trial. Am J Clinl Nutr, 100(3), 974-81.
- Supakatisant, C., & Phupong, V. (2015). Oral magnesium for relief in pregnancy-induced leg cramps: A randomised controlled trial. Matern Child Nutr, 11(2):139-45.
- Welch, A.A., Kelaiditi, E., Jennings, A., et al. (2016). Dietary magnesium is positively associated with skeletal muscle power and indices of muscle mass and may attenuate the association between circulating C-reactive protein and muscle mass in women. J Bone and Miner Res, 31(2), 317-25.
- Dominguez, L.J., Veronese, N., Ciriminna, S., et al. (2023). Association between serum magnesium and fractures: A systematic review and meta-analysis of observational studies. Nutrients, 15(6), 1304.
- Groenendijk, I., van Delft, M., Versloot, P., et al. (2022). Impact of magnesium on bone health in older adults: A systematic review and meta-analysis. Bone, 154, 116233.
- Azem, R., Daou, R., Bassil, E., et al. (2020). Serum magnesium, mortality and disease progression in chronic kidney disease. BMC Nephrol, 21(1), 49.
- Kashihara, Y., Terao, Y., Yoda, K., et al. (2019). Effects of magnesium oxide on pharmacokinetics of L-dopa/carbidopa and assessment of pharmacodynamic changes by a model-based simulation. Eur J Clin Pharmacol, 75(3), 351-61.
- Imaoka, A., Hattori, M., Akiyoshi, T., et al. (2014). Decrease in ciprofloxacin absorption by polyvalent metal cations is not fully attributable to chelation or adsorption. Drug Metab Pharmacokinet, 29(5), 414-8.
- Sompolinsky, D., & Samra, Z. (1972). Influence of magnesium and manganese on some biological and physical properties of tetracycline. J Bacteriol, 110(2), 468-76.
- Neuvonen, P.J., & Kivisto, K.T. (1991). The effects of magnesium hydroxide on the absorption and efficacy of two glibenclamide preparations. Br J Clin Pharmacol, 32(2), 215-20.
- Natural Medicines. (2023). Magnesium [monograph]. Retrieved from: https://naturalmedicines.therapeuticresearch.com
- Karimzadeh, I., Heydari, M., Ramzi, M., et al. (2016). Frequency and associated factors of amphotericin b nephrotoxicity in hospitalized patients in hematology-oncology wards in the southwest of Iran. Nephrol Mon, 8(5), e39581.
- Gottlieb, S.S., Baruch, L., Kukin, M.L., et al. (1990). Prognostic importance of the serum magnesium concentration in patients with congestive heart failure. J Am Coll Cardiol, 16(4), 827-31.
- Palmery, M., Saraceno, A., Vaiarelli, A., et al. (2013). Oral contraceptives and changes in nutritional requirements. Eur Rev Med Pharmacol Sci, 17(13), 1804-13.
- Huycke, M.M., Naguib, M.T., Stroemmel, M.M., et al. (2000). A double-blind placebo-controlled crossover trial of intravenous magnesium sulfate for foscarnet-induced ionized hypocalcemia and hypomagnesemia in patients with AIDS and cytomegalovirus infection. Antimicrob Agents Chemother, 44(8), 2143-8.
- Shaoul, R., Wolff, R., Seligmann, H., et al. (2001). Symptoms of hyperphosphatemia, hypocalcemia, and hypomagnesemia in an adolescent after the oral administration of sodium phosphate in preparation for a colonoscopy. Gastrointest Endosc, 53(6), 650-2.
- Gratreak, B.D.K., Swanson, E.A., Lazelle, R.A., et al. (2020). Tacrolimus-induced hypomagnesemia and hypercalciuria requires FKBP12 suggesting a role for calcineurin. Physiol Rep, 8(1), e14316.