L-Glutamine

L-Glutamine

with Theracurmin™

306 g ( SKU: 9252, NPN: 80065236 )

Benefits

  • Provides 5 g of L-glutamine and 30 mg of Theracurmin per serving
  • Targets multiple pathways of inflammation and protein synthesis to improve muscle repair and recovery following exercise
  • Provides immune and digestive system support
  • Theracurmin has higher bioavailability and more rapid absorption in humans, compared to standard curcumin1,2
  • Powder formulation allows for flexible and convenient dosing
  • Suitable for vegetarians/vegans

Feature Summary

L-glutamine with Theracurmin provides two complementary nutrients that target inflammation and support intestinal and musculoskeletal health, especially in response to exercise. L-glutamine is the most plentiful amino acid in the body, a Krebs cycle intermediary of particular importance to intestinal and immune cells, and one known to be depleted following strenuous physical activity.3 L-glutamine supplementation has been shown to prevent an exercise-induced increase in intestinal permeability, by promoting tight junction stability, upregulating anti-inflammatory cytokine production, and suppressing inflammation, notably NF-κB activation.4 L-glutamine also stimulates protein synthesis pathways while inhibiting protein degradation, and has been shown to improve muscle recovery, reduce soreness, and limit muscle damage following exercise.5,6,7

Curcumin has well-established anti-inflammatory effects with multiple molecular targets, including NF-κB, as well as cyclooxygenases and lipoxygenases, and it also promotes recovery of intestinal integrity by enhancing tight junction protein expression.8,9,10 Curcumin supplementation has been shown to mitigate damage to muscles following exercise, reduce pain due to delayed onset muscle soreness, and enhance the recovery of muscle performance.11 Theracurmin specifically has been shown to prevent both an increase in creatine kinase and muscle degradation following eccentric exercise.12 Theracurmin has been proven effective for symptom relief and for reducing the need for rescue medication among participants with knee osteoarthritis in a prospective clinical trial.13 L-glutamine and Theracurmin both target multiple mechanisms associated with inflammation, muscle repair, and function.14

Medicinal Ingredients

Each Serving (5.2 g) Contains:
Micronized L-Glutamine 5 g
Theracurmin® Curcumin* from Turmeric
  (Curcuma longa) (rhizome) 30 mg
*A highly bioavailable form of curcumin – the most active curcuminoid in turmeric

Non-Medicinal Ingredients

Maltose, gum ghatti, dextrin, citric acid.

Dosage:

Recommended Adult Dose: Take 1 serving (5.2 g) per day or as directed by a health care practitioner. Mix product well in 375–500 mL of liquid (water, juice, etc.) immediately before consumption.

Warnings:

Ensure to drink enough fluid before, during, and after exercise. Consult a health care practitioner if you are following a low-protein diet. Consult a health care practitioner prior to use if you are pregnant or breastfeeding, taking antiplatelet medication or blood thinners, have gallstones or a bile duct obstruction, or have stomach ulcers or excess stomach acid. Keep out of reach of children.

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Drug Interactions

Caution is advised when taking with anticoagulant medications. Curcumin has been shown to enhance the effect of some chemotherapeutic medications, as well as inhibit the effect of others, and should only be used under medical supervision by those receiving chemotherapy. A reduction in the dose of medications used to treat diabetes may be necessary, as curcumin enhances the effect of insulin. Similarly, L-glutamine has been shown to reduce levels of HbA1c and fructosamine among well-controlled diabetics, thus requiring monitoring of anti-glycemic medication use.15

  1. Sasaki, H., Sunagawa, Y., Takahashi, K., et al. (2011). Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull, 34(5), 660-5.
  2. Chung, H., Yoon, S.H., Cho, J.-Y., et al. (2021). Comparative pharmacokinetics of Theracurmin, a highly bioavailable curcumin, in healthy adult subjects. Int J Clin Pharmacol Ther, 59(10), 684-90.
  3. Agostini, F., & Biolo, G. (2010). Effect of physical activity on glutamine metabolism. Curr Opin Clin Nutr Metab Care, 13(1), 58-64.
  4. Zuhl, M., Dokladny, K., Mermier, C., et al. (2015). The effects of acute oral glutamine supplementation on exercise-induced gastrointestinal permeability and heat shock protein expression in peripheral blood mononuclear cells. Cell Stress Chaperones, 20(1), 85-93.
  5. Lambertucci, A.C., Lambertucci, R.H., Hirabara, S.M., et al. (2012). Glutamine supplementation stimulates protein-synthetic and inhibits protein-degradative signaling pathways in skeletal muscle of diabetic rats. PLoS One, 7(12), e50390.
  6. Legault, Z., Bagnall, N., & Kimmerly, D.S. (2015). The Influence of oral L-glutamine supplementation on muscle strength recovery and soreness following unilateral knee extension eccentric exercise. Int J Sport Nutr Exerc Metab, 25(5), 417-26.
  7. Córdova-Martínez, A., Caballero-García, A., Bello, H.J., et al. (2021). Effect of glutamine supplementation on muscular damage biomarkers in professional basketball players. Nutrients, 13(6), 2073.
  8. Shakibaei, M., John, T., Schulze-Tanzil, G., et al. (2007). Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: implications for the treatment of osteoarthritis. Biochem Pharmacol, 73(9), 1434-45.
  9. Wongcharoen W, Phrommintikul A. (2009). The protective role of curcumin in cardiovascular diseases. Int J Cardiol. 133(2):145-51.
  10. Tian, S., Guo, R., Wei, S., et al. (2016). Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-α related mechanism. Korean J Physiol Pharmacol, 20(2), 147-52.
  11. Nicol, L.M., Rowlands, D.S., Fazakerly, R., et al. (2015). Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol, 115(8), 1769-77.
  12. Tanabe, Y., Maeda, S., Akazawa, N., et al. (2015). Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin. Eur J Appl Physiol, 115(9), 1949-57.
  13. Nakagawa, Y., Mukai, S., Yamada, S., et al. (2014). Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci, 19(6), 933-9.
  14. Amirato, G.R., Borges, J.O., Marques, D.L., et al. (2021). L-glutamine supplementation enhances strength and power of knee muscles and improves glycemia control and plasma redox balance in exercising elderly women. Nutrients, 13(3), 1025.
  15. Samocha-Bonet, D., Chisholm, D.J., Gribble, F.M., et al. (2014). Glycemic effects and safety of L-glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study. PLoS One, 9(11), e113366.