Enhanced B Complex

Enhanced B Complex

Biologically active B vitamins

60 Vegetarian Capsules ( SKU: 9427, NPN: 80120273 )


  • Supports energy production, nutrient metabolism, liver function, immune function, and red blood cell production
  • Helps maintain healthy hair, skin, and nails
  • Contains full-spectrum B vitamins in the most metabolically active forms, which do not require conversion by the liver for utilization
  • Provides a clinically effective dose of the most active and bioavailable form of folate, Quatrefolic
  • Each capsule also provides the most bioactive and bioavailable forms of each B vitamin, including methylcobalamin (B12), riboflavin 5’-phosphate (B2), and pyridoxal 5’-phosphate (B6)
  • Suitable for vegetarians and vegans

Feature Summary

Enhanced B Complex from Bioclinic Naturals is a one-per-day formula providing full-spectrum B vitamins in their most metabolically active forms. B vitamins are cofactors for many important mechanisms in the body, including nutrient metabolism, energy production, growth and development, and liver function. B vitamins also help support immunity, red blood cell production, and iron metabolism, as well as healthy skin, hair, and nails. This formula contains B vitamins in their active forms, such as vitamins B12 (methylcobalamin) and B6 (pyridoxal 5’-phosphate), to support nervous system function. It also includes 50 mg of choline and 400 mcg of folate (Quatrefolic). In addition, this formula contains vitamins B1, B2, B5, and B6, and niacin, with additional support from biotin and inositol. This convenient all-in-one B complex is an ideal supplement to help support metabolism, energy, and overall health.

Quatrefolic is an active form of folate at the cellular level, the form found in circulation and the only one to cross the blood-brain barrier. It may also be the optimal form for preventing neural tube defects.(1) It does not need to be converted to an active form by the enzyme methylene tetrahydrofolate reductase (MTHFR), known to have common single-nucleotide polymorphisms.(2) Quatrefolic acid administration has been associated with higher peak (6S)-5-MTHF levels than both folic acid and calcium 5-MTHF, even in those with high-functioning MTHFR polymorphisms.(2–4)

Methylcobalamin is a cofactor for B12-dependent enzymes and has direct biological activity. When combined with other B vitamins, it has been shown to reduce the risk of macular degeneration migraines, with effectiveness sometimes modulated by MTHFR status.(5–8)

Medicinal Ingredients

Each Vegetarian Capsule Contains:
Vitamin B1 (Thiamine Hydrochloride, Benfotiamine) 31.7 mg
Vitamin B2 (Riboflavin 5’-Phosphate Sodium) 10 mg
Niacin (Inositol Hexanicotinate) 100 mg
Pantothenic Acid (Calcium d-Pantothenate) 100 mg
Vitamin B6 (Pyridoxal 5’-Phosphate Monohydrate) 25 mg
Vitamin B12 (Methylcobalamin) 500 mcg
Folate (from (6S)-5-Methyltetrahydrofolic Acid (MTHF), Glucosamine Salt, Quatrefolic®) 400 mcg
Biotin 250 mcg
Choline (Dihydrogen Citrate) 50 mg
Inositol (Inositol, Inositol Hexanicotinate) 50 mg

Non-Medicinal Ingredients

Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.


Recommended Adult Dose (19 years and older): 1 capsule per day with food or as directed by a health care practitioner.


Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.


No significant contraindications.

Drug Interactions

Although several classes of drugs, such as aminoglycosides, anticonvulsants, bile acid sequestrants, and proton pump inhibitors; antihyperglycemic medications (Metformin); and acne therapy (isotretinoin) are known to either interfere with B12 absorption or function, there are no known negative interactions caused by B12 supplementation with any medications.(9–12) Metformin has been shown to deplete B12 and folate, and supplementation with only B12 in diabetics may be preferable.(13) Folate may decrease the effectiveness of phenobarbital, phenytoin, or primidone, when given concurrently; it may also decrease the effectiveness of pyrimethamine.(14) When taken with amiodarone, vitamin B6 may increase photosensitivity. Theoretically, it may have additive effects with antihypertensive drugs.(15) Theoretically, inositol may have additive effects with antidiabetes drugs.(16) Theoretically, riboflavin may decrease the effectiveness of tetracycline antibiotics.(17) Niacin may decrease the effectiveness of uricosurics, antidiabetics, and thyroid hormone. Theoretically, it may have additive effects with antiocoagulant, antiplatelet, and antihypertensive drugs. When taken with statins, niacin may increase the risk of myopathy, and when taken with hepatotoxic drugs, it may increase the risk of hepatotoxicity.(18)

1. Obeid, R., Holzgreve, W., & Pietrzik, K. (2013). Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects? J Perinat Med. 41(5), 469-83.

2. Cortese, C., & Motti, C. (2001). MTHFR gene polymorphism, homocysteine and cardiovascular disease. Public Health Nutr, 4(2B), 493-7.

3. Miraglia, N., Agostinetto, M., Bianchi, D., et al. (2016). Enhanced oral bioavailability of a novel folate salt: Comparison with folic acid and a calcium folate salt in a pharmacokinetic study in rats. Minerva Ginecol, 68(2), 99-105.

4. Prinz-Langenohl, R., Brämswig, S., Tobolski, O., et al. (2009). [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol, 158(8), 2014-21.

5. Ji, Y., Tan, S., Xu, Y., et al. (2013). Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: A meta-analysis. Neurology, 81(15), 1298-307.

6. Lea, R., Colson, N., Quinlan, S., et al. (2009). The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics, 19(6), 422-8.

7. Bjelland, I., Tell, G.S., Vollset, S.E., et al. (2003). Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: The Hordaland Homocysteine Study. Arch Gen Psychiatry, 60(6), 618-26.

8. Christen, W.G., Glynn, R.J., Chew, E.Y., et al. (2009). Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: The Women’s Antioxidant and Folic Acid Cardiovascular Study. Arch Intern Med, 169(4):335-41.

9. McColl, K.E. (2009). Effect of proton pump inhibitors on vitamins and iron. Am J Gastroenterol, 104 (Suppl 2), S5-9.

10. Aslan, K., Bozdemir, H., Unsal, C., et al. (2008). The effect of antiepileptic drugs on vitamin B12 metabolism. Int J Lab Hematol, 30(1), 26-35.

11. Markkanen, T., Salmi, H.A., & Sotaniemi, E. (1965). Effect of neomycin treatment on the vitamin B12 content of human serum and urine. Z Vitam Horm Fermentforsch, 14(1), 66-71.

12. Karadag, A.S., Tutal, E., Ertugrul, D.T., et al. (2011). Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: Non-controlled study. Int J Dermatol, 50(12), 564-9.

13. Xu, L., Huang, Z., He, X., et al. (2013). Adverse effect of metformin therapy on serum vitamin B12 and folate: Short-term treatment causes disadvantages? Med Hypotheses, 81(2), 149-51.

14. Natural Medicines Comprehensive Database. (2022). Folic Acid [monograph]. Retrieved from http://naturalmedicines.therapeuticresearch.com

15. Natural Medicines Comprehensive Database. (2022). Vitamin B6 [monograph]. Retrieved from http://naturalmedicines.therapeuticresearch.com

16. Natural Medicines Comprehensive Database. (2022). Inositol [monograph]. Retrieved from http://naturalmedicines.therapeuticresearch.com

17. Natural Medicines Comprehensive Database. (2022). Riboflavin [monograph]. Retrieved from http://naturalmedicines.therapeuticresearch.com

18. Natural Medicines Comprehensive Database. (2022). Niacin [monograph]. Retrieved from http://naturalmedicines.therapeuticresearch.com