Digestive Enzymes
267 mg
60 Vegetarian Capsules ( SKU: 9503, NPN: 80072201 )
Benefits
- Provides fungal and bacterial proteases to hydrolyze proline-containing peptides that are difficult to digest, such as gluten and casein
- Provides broad-spectrum carbohydrate digestion with plant-based papain, bromelain, and fungal digestive enzymes
- High-potency formulation allows for easy dosing, with a 267 mg enzyme blend delivered in each vegetarian capsule
- Completely suitable for vegetarians
Feature Summary
Digest-ProGD HP is a high-potency proprietary enzyme blend for comprehensive carbohydrate digestion. It provides fungal proteases derived from Aspergillus oryzae, bacterial protease from Bacillus subtilis, and comprehensive carbohydrate digestive support from papain, bromelain, and fungal digestive enzymes. Aspergillus oryzae extracts are rich in prolyl endopeptidases and dipeptidyl peptidase IV (DPP-IV) – a multifunctional serine protease that targets proline-containing peptides, such as those found in both gliadin and casein, both proteolytically resistant proteins.1−4
Indeed, protease activity from Aspergillus oryzae targets the proline-rich 33-mer of gliadin, perhaps the most immunotoxic peptide derived from gliadin. 5 The antigenic and immunomodulatory proline-rich proteins found in gluten are thought to trigger an inflammatory response in patients with either celiac disease or gluten sensitivity, often because of accidental gluten exposure, even for people on a gluten-free diet. 6 Supplementation with protease from Aspergillus oryzae has also been linked to a bifidogenic effect in animals, suggesting a potential probiotic effect, as well as an increase in gut-protective amino acids. 7,8
In addition to fungal and bacterial proteases, Digest-ProGD HP provides alpha-amylase, cellulose, and hemicellulose activity for comprehensive carbohydrate digestion support.
Medicinal Ingredients
| Each Vegetarian Capsule Contains: | ||
| Enzyme Blend | 267 mg | |
| Fungal Protease*1 | 690 FCC SAP | 125.47 mg |
| Bacterial Protease*2 | 75,000 FCC PC | 75 mg |
| Fungal Protease*1 Providing 163 DPP-IV Enzyme Activity |
6,700 FCC HUT | 24.36 mg |
| Alpha-Amylase*1 | 2,800 FCC DU | 18.67 mg |
| Bromelain*3 | 315,000 FCC PU | 9.55 mg |
| Papain*4 | 315,000 FCC PU | 7.5 mg |
| Cellulase*5 | 680 FCC CU | 3.78 mg |
| Hemicellulase*6 | 1,875 FCC HCU | 2.34 mg |
| *1Aspergillus flavus var. oryzae (whole), *2Bacillus subtilis (whole), *3Ananas comosus var. comosus (pineapple stem), *4Carica papaya (fruit),*5Trichoderma longibrachiatum (whole), *6Aspergillus niger (whole) | ||
| FCC: Food Chemical Codex; SAP: Spectrophotometric Acid Protease Unit; PC: Protease Unit; HUT: Hemoglobin Unit on the Tyrosine Basis; DU: Dextrinizing Unit; PU: Papain Unit; CU: Cellulase Unit; HCU: Hemicellulase Unit. | ||
Non-Medicinal Ingredients
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant).
Dosage:
Recommended Adult Dose: 1 capsule 3 times per day with meals or as directed by a health care practitioner. Consult a health care practitioner for prolonged use.
Warnings:
Consult a health care practitioner prior to use if you have diabetes or a gastrointestinal lesion/ulcer, are taking anticoagulant/blood thinner agents, anti-inflammatory agents, or antibiotics, are having surgery, are pregnant or breastfeeding, or have an allergy to latex or fruits (e.g., avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, and tomato). Stop use if hypersensitivity/allergy, nausea, vomiting, or diarrhea occurs. Keep out of reach of children.
Allergens:
Contains no artificial colours, preservatives, or sweeteners; no sugar, wheat, gluten, yeast, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Contraindications
Consult a health care practitioner prior to use if you have diabetes, a gastrointestinal lesion, ulcer, are taking an anticoagulant, blood thinner, anti-inflammatory, antibiotic, or are having surgery, are pregnant or breastfeeding, or have allergy to latex or fruits (avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, tomato).
Drug Interactions
No known drug interactions.
- Mulvihill, E.E., Drucker, D.J. (2014). Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors. Endocr Rev, 35(6), 992-1019.
- Nongonierma, A.B., FitzGerald, R.J. (2014). Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chem, 145, 845-52.
- Lambeir, A.M., Durinx, C., Scharpé, S., et al. (2003). Dipeptidyl-peptidase IV from bench to bedside: An update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci, 40(3), 209-94.
- Pourmohammadi, K., Abedi, E. (2021). Hydrolytic enzymes and their directly and indirectly effects on gluten and dough properties: An extensive review. Food Sci Nutr, 9(7), 3988-4006.
- Eugster, P.J., Salamin, K., Grouzmann, E., et al. (2015). Production and characterization of two major Aspergillus oryzae secreted prolyl endopeptidases able to efficiently digest proline-rich peptides of gliadin. Microbiol, 161(12), 2277-88.
- Cerf-Bensussan, N., Matysiak-Budnik, T., Cellier, C., et al. (2007). Oral proteases: A new approach to managing coeliac disease. Gut, 56(2), 157-60.
- Yang, Y., Iwamoto, A., Kumrungsee, T., et al. (2017). Consumption of an acid protease derived from Aspergillus oryzae causes bifidogenic effect in rats. Nutr Res, 44, 60-6.
- Yang, Y., Kumrungsee, T., Kuroda, M., et al. (2019). Feeding Aspergillus protease preparation combined with adequate protein diet to rats increases levels of cecum gut-protective amino acids, partially linked to Bifidobacterium and Lactobacillus. Biosci Biotechnol Biochem, 83(10), 1901-11.