Ashwagandha

Ashwagandha

Adaptogen, Made with Organic Ashwagandha Extract

600 mg

60 Vegetarian Capsules ( SKU: 9291, NPN: 80116512 )

Benefits

  • Provides 600 mg per capsule of proprietary organic, clinically studied KSM-66 Ashwagandha™ extract
  • Features dairy-free KSM-66 extract made from plant roots only, with randomized clinical trials documenting efficacy and safety for a range of conditions
  • Extracted using a proprietary “green chemistry” water-based process, without the use of alcohol or any chemical solvents 
  • Standardized to 5% withanolides, providing diverse physiological benefits
  • Suitable for vegetarians and vegans

Feature Summary

Ashwagandha (Withania somnifera) has a long history of use as a foundational adaptogen in Ayurvedic medicine. It is widely recognized to have broad benefits, including increased resistance to stress and anxiety, enhanced physical performance and immune function, as well as improved fertility, sleep, and neurological function.1,2 Its diverse phytochemistry includes withanolides, sitoindosides, phenolics, and flavonoids, which help explain its diverse physiological actions, ranging from cardio- and neuroprotective effects, to anti-inflammatory and anxiolytic effects.3,4

KSM-66 is a full-spectrum extract of ashwagandha that uses only the roots of the plant, notable for the extensive range of randomized and controlled trials documenting its efficacy. Clinical trials have demonstrated a significant improvement in both symptom scores and cortisol levels among participants with chronic stress, along with improved weight control and cravings in this population.5,6 It has also been shown to improve general well-being, sleep quality, and mental alertness in older adults, as well as memory and executive function in individuals with cognitive impairment.7,8 Clinical trials document an increase in cardiorespiratory endurance, measured by VO2 max, among male and female athletes using KSM-66, and greater increases in muscle mass and strength when coupled with resistance training.9,10 In addition, the KSM-66 extract has demonstrated benefits for increasing sleep quality, improving sexual function in men and women, restoring spermatogenic activity in oligospermic men, and enhancing thyroid function in individuals with subclinical hypothyroidism.11-15

Medicinal Ingredients

Each Vegetarian Capsule Contains:
Organic KSM-66 Ashwagandha® Extract 12:1 (Withania somnifera) (root) (5% Withanolides) 600 mg

Non-Medicinal Ingredients

Vegetarian capsule (pullulan, purified water), organic Oryza sativa (rice) hull powder, organic maltodextrin, organic Oryza sativa (rice) bran extract, organic gum arabic, organic sunflower oil.
Contains 85% organic ingredients

Dosage:

Recommended Adult Dose: 1 capsule per day or as directed by a health care practitioner. For use beyond 12 weeks, consult a health care practitioner. Sleep quality, relief of restlessness, athletic support: Use for a minimum of 8 weeks to see beneficial effects.

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

Drug Interactions

No direct drug interactions, but may have a hypoglycemic effect that should be monitored when taken concomitantly with diabetes medications.16,17

  1. Saleem, S., Muhammad, G., Hussain, M.A., et al. (2020). Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective. Iran J Basic Med Sci, 23(12), 1501-26.
  2. Dar, N.J., Hamid, A., & Ahmad, M. (2015). Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cell Mol Life Sci, 72(23), 4445-60.
  3. Candelario, M., Cuellar, E., Reyes-Ruiz, J.M., et al. (2015). Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors. J Ethnopharmacol, 171, 264-72.
  4. Mandlik Ingawale, D.S., & Namdeo, A.G. (2021). Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. J Diet Suppl, 18(2), 183-226.
  5. Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med, 34(3), 255-62.
  6. Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017). Body weight management in adults under chronic stress through treatment with Ashwagandha root extract: A double-blind, randomized, placebo-controlled trial. J Evid Based Complementary Altern Med, 22(1), 96-106.
  7. Kelgane, S.B., Salve, J., Sampara, P., et al. (2020). Efficacy and tolerability of Ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. Cureus, 12(2), e7083.
  8. Choudhary, D., Bhattacharyya, S., & Bose, S. (2017). Efficacy and safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions. J Diet Suppl, 14(6), 599-612.
  9. Choudhary, B., Shetty, A., & Langade, D.G. (2015). Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. Ayu, 36(1), 63-8.
  10. Wankhede, S., Langade, D., Joshi, K., et al. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr, 12, 43.
  11. Langade, D., Kanchi, S., Salve, J., et al. (2019). Efficacy and safety of Ashwagandha (Withania somnifera) root extract in insomnia and anxiety: A double-blind, randomized, placebo-controlled study. Cureus, 11(9), e5797.
  12. Langade, D., Thakare, V., Kanchi, S., et al. (2021). Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study. J Ethnopharmacol, 264, 113276.
  13. Ambiye, V.R., Langade, D., Dongre, S., et al. (2013). Clinical evaluation of the spermatogenic activity of the root extract of Ashwagandha (Withania somnifera) in oligospermic males: A pilot study. Evid Based Complement Alternat Med, 2013, 571420.
  14. Dongre, S., Langade, D., & Bhattacharyya, S. (2015). Efficacy and safety of Ashwagandha (Withania somnifera) root extract in improving sexual function in women: A pilot study. Biomed Res Int, 2015, 284154.
  15. Sharma, A.K., Basu, I., & Singh, S. (2018). Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: A double-blind, randomized placebo-controlled trial. J Altern Complement Med, 24(3), 243-8.
  16. Tandon, N., & Yadav, S.S. (2020). Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments. J Ethnopharmacol, 255, 112768.
  17. Durg, S., Bavage, S., & Shivaram, S.B. (2020). Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res, 34(5), 1041-59.