Iron Bisglycinate

Iron Bisglycinate

Helps Form Red Blood Cells

45 mg

60 Vegetarian Capsules ( SKU: 9505, NPN: 80107078 )

Benefits

  • Provides a clinical dose of 45 mg of elemental iron per capsule
  • Highly absorbable form, iron bisglycinate chelate, has greater bioavailability than standard forms
  • Comparable to ferrous sulphate at ¼ to ½ the same dose of elemental iron
  • Iron bisglycinate chelate is significantly more tolerable than commonly used forms, allowing for continued use and enhancing its effectiveness in replenishing iron stores
  • Suitable for vegetarians and vegans 

Feature Summary

Iron deficiency remains the most prevalent nutrient deficiency as well as the most common cause of anemia worldwide.1,2  Depleted iron stores impair mitochondrial function and cellular respiration even in the absence of anemia, particularly in metabolically active cells, contributing to symptoms ranging from fatigue and exercise intolerance to cognitive and cardiac impairment.3,4  The mainstay for replenishing iron levels in the majority of cases is oral iron supplementation, which is preferable to parenteral administration (injections) in the absence of severe symptoms or contraindications.5

However, many oral iron formulations have limited tolerability, primarily due to frequent gastrointestinal symptoms.6  In contrast, iron bisglycinate chelate, which is composed of two glycine molecules chelated to ferrous iron (Fe2+), has demonstrated significantly greater bioavailability than standard forms of iron such as ferrous sulphate, ferrous fumarate, and polymaltose iron. This form has much greater tolerability, allowing for effective restoration of iron levels using lower doses.7,8  For example, at ¼ to ½ the dose of ferrous sulphate, iron bisglycinate chelate has shown similar effects on hemoglobin, ferritin, and other markers of hematological status in controlled trials, with better tolerability.9,10  It has also been found to be effective and well-tolerated in a variety of patient populations, including pregnant women and children with celiac disease.11,12  45 mg of elemental iron per capsule, higher than most formulations, is consistent with current recommendations for restoring depleted iron levels in pregnant women, though lower than the threshold typically associated with adverse effects.13,14

Medicinal Ingredients

Each Vegetarian Capsule Contains:
Iron (Bisglycinate) 45 mg

Non-Medicinal Ingredients

Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), stearic acid, silica.

Dosage:

Recommended Adult Dose: 1 capsule per day or as directed by a health care practitioner. Take with food, a few hours before or after taking other medications or natural health products.

Warnings:

Keep out of reach of children. There is enough iron in this package to seriously harm a child. Some people may experience constipation, diarrhea, and/or vomiting. Stop use if hypersensitivity occurs.

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

Oral iron supplementation should not be used by individuals with hereditary hemochromatosis, hemosiderosis, or a history of hemolytic anemia without supervision. All cases of anemia should be thoroughly evaluated, and progress monitored.

Drug Interactions

Some medications interfere with the absorption of iron or have their own absorption reduced by iron, including antacids, methyldopa/levodopa, fluoroquinolones, penicillin, and tetracyclines, and should be taken several hours apart. 

  1. Muñoz, M., Gómez-Ramírez, S., Besser, M., et al. (2017). Current misconceptions in diagnosis and management of iron deficiency. Blood Transfus, 15(5), 422-37.
  2. Al-Naseem, A., Sallam, A., Choudhury, S., et al. (2021). Iron deficiency without anaemia: a diagnosis that matters. Clin Med (Lond), 21(2), 107-13.
  3. Portugal-Nunes, C., Castanho, T.C., Amorim, L., et al. (2020). Iron status is associated with mood, cognition, and functional ability in older adults: a cross-sectional study. Nutrients, 12(11), 3594.
  4. Hoes, M.F., Grote Beverborg, N., Kijlstra, J.D., et al. (2018). Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function. Eur J Heart Fail, 20(5), 910-9.
  5. Pasricha, S.R., Tye-Din, J., Muckenthaler, M.U., et al. (2021). Iron deficiency. Lancet, 397(10270), 233-48.
  6. Tolkien, Z., Stecher, L., Mander, A.P., et al. (2015). Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS One, 10(2), e0117383.
  7. Boetti, T., Cester, E.A., Bertino, E., et al. (2018). Efficacy of supplementation with iron sulfate compared to iron bisglycinate chelate in preterm infants. Curr Pediatr Rev, 14(2), 123-9.
  8. Name, J.J., Vasconcelos, A.R., & Valzachi Roch Maluf, M.C. (2018). Iron bisglycinate chelate and polymaltose iron for the treatment of iron deficiency anemia: A pilot randomized trial. Curr Pediatr Rev, 14(4), 261-8.
  9. Ferrari, P., Nicolini, A., Manca, M.L., et al. (2012). Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: Comparison between oral ferrous bisglycinate chelate and ferrous sulfate. Biomed Pharmacother, 66(6), 414-8.
  10. Milman, N., Jønsson, L., Dyre, P., et al. (2014). Ferrous bisglycinate 25 mg iron is as effective as ferrous sulfate 50 mg iron in the prophylaxis of iron deficiency and anemia during pregnancy in a randomized trial. J Perinat Med, 42(2), 197-206.
  11. Mazza, G.A., Marrazzo, S., Gangemi, P., et al. (2019). Oral iron absorption test with ferrous bisglycinate chelate in children with celiac disease. Minerva Pediatr, 71(2), 139-43.
  12. Melamed, N., Ben-Haroush, A., Kaplan, B., et al. (2007). Iron supplementation in pregnancy—does the preparation matter? Arch Gynecol Obstet, 276(6), 601-4.
  13. Pavord, S., Daru, J., Prasannan, N., et al. (2020). BSH Committee. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol, 188(6), 819-30.
  14. Stoffel, N.U., von Siebenthal, H.K., Moretti, D., et al. (2020). Oral iron supplementation in iron-deficient women: How much and how often? Mol Aspects Med, 75,100865.