60 Vegetarian Capsules ( SKU: 9274, NPN: 80040662 )
- R-Alpha-Lipoic Acid provides only the naturally occurring R-isomer, the only form utilized by mitochondrial enzymes, and only one synthesized in humans
- R-isomer has greater biological activity than the racemic mixture often used in supplements, a combination of the R- and S-isomers
- R-isomer supplementation results in higher total plasma levels, as well as a shorter time to reach maximum levels in older individuals compared to racemic mixture
- ALA neutralizes reactive oxygen species and is a potent inducer of phase 2 antioxidant enzymes
- Enhances mitochondrial function and supports glutathione synthesis
- Suitable for vegetarians/vegans
Alpha-lipoic acid (ALA) is a potent antioxidant, anti-inflammatory, neuroprotective, and mitochondrial nutrient. The R-isomer of ALA is a cofactor for mitochondrial enzymes and a substrate for glutathione reductase, it participates in the citric acid cycle and ATP production, and recycles other antioxidants, including vitamins C, E, CoQ10, and glutathione.1
R-Alpha-Lipoic Acid provides only the R-isomer, which increased plasma levels nearly 1.5 times higher in older populations than the commonly used racemic mixture (combined R- and S-isomers).2 ALA has also accelerates wound healing when combined with hyperbaric oxygen therapy, particularly the R-isomer.3,4 The R-isomer has a greater neuroprotective effect in an in vivo model of brain vascular injury, due to the S-isomer’s negative influence or lack of biological activity.5
ALA improved glycemic control and insulin resistance in type 2 diabetics, with clear benefit for the prevention and treatment of peripheral neuropathy.6,7,8 It improved endothelial function among individuals with impaired glucose tolerance, and increased weight loss among obese individuals.9,10 The R-isomer was significantly more effective than the S-isomer at improving insulin-stimulated glucose transport and metabolism in insulin resistant animal models.11
Serving Size: 1 Vegetarian Capsule
Servings per Container: 60
Each Vegetarian Capsule Contains:
R-Alpha-Lipoic Acid.........................................................................100 mg
Microcrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water), silica, vegetable grade magnesium stearate (lubricant).
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
1 capsule 2 times per day or as directed by a health care practitioner.
No known contraindications. Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you have diabetes. Keep out of reach of children.
ALA was shown to prevent drug-induced weight gain associated with atypical antipsychotics without reducing drug efficacy. Caution should be used with antidiabetes medications, as they may have additive hypoglycemic effects. Long term use may warrant low dose copper and/or thiamine supplementation.
- Liu J. The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. Neurochem Res. 2008 Jan;33(1):194-203.
- Keith DJ, Butler JA, Bemer B, et al. Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study. Pharmacol Res. 2012 Sep;66(3):199-206.
- Alleva R, Nasole E, Di Donato F, et al. alpha-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy. Biochem Biophys Res Commun. 2005 Jul 29;333(2):404-10.
- Nasole E, Nicoletti C, Yang ZJ, et al. Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing. J Enzyme Inhib Med Chem. 2013 Jan 30. [Epub ahead of print]
- Tomassoni D, Amenta F, Amantini C, et al. Brain activity of thioctic acid enantiomers: in vitro and in vivo studies in an animal model of cerebrovascular injury. Int J Mol Sci. 2013 Feb 26;14(3):4580-95.
- Kamenova P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens). 2006 Oct-Dec;5(4):251-8.
- Han T, Bai J, Liu W, et al. A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. Eur J Endocrinol. 2012 Oct;167(4):465-71.
- Tang J, et al. Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy. Neurologist. 2007 May;13(3):164-7.
- Xiang G, Pu J, Yue L, et al. α-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose. Metabolism. 2011 Apr;60(4):480-5.
- Koh EH, Lee WJ, Lee SA, et al. Effects of alpha-lipoic acid on body weight in obese subjects. Am J Med. 2011 Jan;124(1):85.e1-8.
- Streeper RS, Henriksen EJ, Jacob S, et al. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol. 1997 Jul;273(1 Pt 1):E185-91.