PreFoundation™

PreFoundation™

Prenatal Multiple Vitamin & Mineral Formula

90 ( SKU: 9475, NPN: 80067595 )

Benefits

  • Provides highly bioavailable forms and clinical doses of vitamins and minerals critical for optimal prenatal health
  • Contains vitamin D3, K2 (menaquinone-7), and folate as L-5-MTHF – key prenatal vitamins shown to be superior to forms typically used in prenatal formulas
  • Supplies citrate forms of key minerals, including magnesium, calcium, zinc, and copper, 5’phosphate forms of riboflavin and vitamin B6, and iron bisglycinate
  • Suitable for vegetarians

Feature Summary

PreFoundation provides a comprehensive prenatal multivitamin/mineral, with optimal dosing and bioavailable forms of each nutrient. Vitamin D3 has been shown to restore vitamin D levels more effectively than vitamin D2, with higher maternal levels linked to lower risk of ADHD, and supplementation linked to lower risk for childhood wheezing and greater birth weight/length.1-4 PreFoundation also provides L-5-MTHF, the bioactive form of folate which bypasses the often impaired enzymatic step needed for folic acid activation. As a result, pregnant women supplementing with L-5-MTHF have been shown to have higher red blood cell folate levels than when supplementing with folic acid.5,6 Greater executive function in children whose mothers supplemented with 5-MTHF during pregnancy has also been observed.7

Potassium iodide provides an essential source of iodine, often deficient in women, and linked to cognitive development in children.8,9 Vitamin K2, as menaquinone-7, is known to have a longer half-life than other forms of vitamin K, and has been associated with greater osteocalcin carboxylation in children, key to optimal bone health.10 PreFoundation also provides highly bioavailable forms of other vitamins and minerals critical to prenatal health. This includes the bioavailable citrate forms of calcium, magnesium,zinc, and copper, and the bisglycinate form of iron, shown to be as effective during pregnancy as twice the dose of iron typically used.11 PreFoundation also provides superior forms of B vitamins, including vitamin B12 as methylcobalamin, as well as the 5’-phosphate forms of riboflavin and vitamin B6.

Medicinal Ingredients

Serving Size: 1 Vegetarian Capsule
Servings per Container: 90

Each Vegetarian Capsule Contains:
Beta-Carotene .............................................................................. 831.67 IU (499 mcg)
Vitamin B1 (Thiamine Hydrochloride) ............................................... 1.6 mg
Vitamin B2 (Riboflavin-5’-Phosphate Sodium) ................................. 1.6 mg
Vitamin B3 (Niacinamide) ................................................................. 10 mg
Vitamin B5 (Pantothenic Acid/Calcium d-Pantothenate) ................. 6.1 mg
Vitamin B6 (Pyridoxal 5’-Phosphate) ................................................. 5 mg
Biotin ..............................................................................................16.6 mcg
Folate (L-5-Methyltetrahydrofolate, Calcium Salt) .................... 333.33 mcg
Vitamin B12 (Methylcobalamin) ................................................ 333.33 mcg
Choline (Dihydrogen Citrate) ..................................................... 25 mg
Vitamin C (Ascorbic Acid) .............................................................. 50 mg
Vitamin D3 (Cholecalciferol) ...................................................... 333 IU (8.325 mcg)
Vitamin E (d-alpha Tocopheryl Acid Succinate) .......................16.6 IU (11.12 mg AT)
Vitamin K2 (Menaquinone) (MK-7) (Natto Bean) ......................20 mcg
Calcium (Malate, Citrate) ........................................................... 66.6 mg
Chromium (Citrate) ....................................................................33.3 mcg
Copper (Citrate) ..........................................................................600 mcg
Iodine (Potassium Iodide) .............................................................50 mcg
Iron (Bisglycinate) ......................................................................... 15 mg
Magnesium (Citrate) ................................................................... 33.3 mg
Manganese (Citrate) ..................................................................... 1.6 mg
Molybdenum (Citrate) ..................................................................16.6 mcg
Selenium (Selenomethionine) ......................................................16.6 mcg
Zinc (Citrate) ..................................................................................... 8.3 mg

Non-Medicinal Ingredients

Vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant), silica, microcrystalline cellulose.

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

Keep out of reach of children. There is enough iron in this package to seriously harm a child. Consult a health care practitioner prior to use if you are taking blood thinners. Some people may experience constipation, diarrhea, and/or vomiting. Hypersensitivity has been known to occur, in which case discontinue use.

Drug Interactions

When taken with a thiazide medication (diuretic), vitamin D may increase the risk for hypercalcemia.

  1. Logan VF, Gray AR, Peddie MC, et al. Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25-hydroxy vitamin D status over the winter months. Br J Nutr. 2013 Mar 28;109(6):1082-8.
  2. Morales E, Julvez J, Torrent M, et al. Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood. Epidemiology. 2015 Jul;26(4):458-65.
  3. Anderson LN, Chen Y, Omand JA, et al. Vitamin D exposure during pregnancy, but not early childhood, is associated with risk of childhood wheezing. J Dev Orig Health Dis. 2015 Aug;6(4):308-16.
  4. Pérez-López FR, Pasupuleti V, Mezones-Holguin E, et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2015 May;103(5):1278-88.e4.
  5. Obeid R, Holzgreve W, Pietrzik K. Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects? J Perinat Med. 2013 Sep 1;41(5):469-83.
  6. Catena A, Muñoz-Machicao JA, Torres-Espínola FJ, et al. Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial. Am J Clin Nutr. 2016 Jan;103(1):115-27.
  7. Lamers Y, Prinz-Langenohl R, Brämswig S, Pietrzik K. Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age. Am J Clin Nutr. 2006 Jul;84(1):156-61.
  8. Pessah-Pollack R, Eschler DC, Pozharny Z, et al. Apparent insufficiency of iodine supplementation in pregnancy. J Womens Health (Larchmt). 2014 Jan;23(1):51-6.
  9. Moleti M, Trimarchi F, Tortorella G, et al. Effects of Maternal Iodine Nutrition and Thyroid Status on Cognitive Development in Offspring: A Pilot Study. Thyroid. 2016 Feb;26(2):296-305.
  10. van Summeren MJ, Braam LA, Lilien MR, et al. The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy pre pubertal children. Br J Nutr. 2009 Oct;102(8):1171-8.
  11. Milman N, Jønsson L, Dyre P, et al. Ferrous bisglycinate 25 mg iron is as effective as ferrous sulfate 50 mg iron in the prophylaxis of iron deficiency and anemia during pregnancy in a randomized trial. J Perinat Med. 2014 Mar;42(2):197-206.