OptiMega-3®

OptiMega-3®

Supports Cardiovascular Health

180 Enteripure™ Softgels ( SKU: 9351, NPN: 80012786 )

Benefits

  • Optimal 2:1 ratio EPA to DHA
  • Pharmaceutical grade omega-3 fish oil blend, USP verified for quality and consistency
  • Highly purified fish oil concentrate free of lipid peroxides and environmental pollutants, including heavy metals, pesticides, dioxins, PCBs, and other harmful compounds
  • Harvested through sustainable fishing practices
  • Sourced from wild anchovies, sardines, and/or mackerel, one of the best natural sources of EPA and DHA
  • Short-lived, small fish, low on the food chain, likely to be less exposed to toxins
  • Wild fish are superior to farmed fish; more omega-3s, less saturated fat, and no antibiotic or hormone residues
  • Highly bioavailable softgel

Feature Summary

Omega-3 fatty acids from fish oil improve a number of cardiovascular risk factors, including lowering of atherosclerotic burden, reducing triglyceride levels and blood pressure, and improving platelet and vascular function.1-4 Not only do these fatty acids modulate risk factors, but controlled clinical trials have shown them to be effective in preventing cardiovascular events, cardiac death and coronary events, particularly in persons at high risk.5 Additionally, omega-3 fatty acids have been associated with reduced all-cause mortality, sudden death, myocardial infarction, as well as stroke.6,7,8 EPA and DHA are essential to the resolution of inflammatory processes as well as tissue repair, by providing the substrates for anti-inflammatory prostaglandins, resolvins, and protectins.9,10 These essential fatty acids are incorporated into membrane phospholipids, affecting cellular membrane organization, ion permeability, intracellular signalling, gene expression, and the activity of membrane-associated proteins.11 Benefits have also been shown for improving overall health, including a wide variety of cardiovascular, inflammatory, and autoimmune conditions, ranging from asthma, cardiac arrhythmias, eczema, and inflammatory bowel disease, to pregnancy and breastfeeding support, rheumatoid arthritis, and neurodegenerative disease.12-17 Purified fish oils are free of many contaminants, such as heavy metals and PCBs, which continue to be a growing problem associated with the consumption of fish.18

Medicinal Ingredients

Serving Size: 1 EnteripureTM Softgel
Servings per Container: 180

Each EnteripureTM Softgel Contains:
Fish Oil Concentrate (Molecularly Distilled, Ultra Purified)
(Anchovy, Sardine and/or Mackerel)........................... 1170 mg
Omega-3 Fatty Acids..................................................... 630 mg
Eicosapentaenoic Acid (EPA)...................................... 400 mg
Docosahexaenoic Acid (DHA)...................................... 200 mg

Non-Medicinal Ingredients

Enteripure softgel (gelatin, glycerin, purified water, pectin), natural vitamin E.

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, corn, egg, shellfish, salt, tree nuts, or GMOs. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

Individuals with an allergy to fish or seafood should use caution, though fish oil is rarely allergenic. Both benefit and risk has been documented for those at risk of or being treated for cardiac arrhythmias, with close supervision indicated.19 Pregnant and nursing women are often advised to consume a minimum of 300 mg DHA per day, and although DHA is recognized as essential to neurological development, no dosage recommendations have been made for children or infants.

Drug Interactions

The antihypertensive effect of fish oil may potentially reduce the need or dosage for blood pressure medications, and patients should be closely monitored. Because fish oil has an antithrombotic effect, caution is advised for those on anticlotting, antiplatelet or anticoagulant medications, or those at high risk of bleeding.20 At doses greater than 3 g per day, hyperglycemia has been observed in diabetics and those with hypertriglyceridemia and close monitoring of patients on antidiabetic medication is recommended. Benefit has been shown when fish oil is taken with statins, SSRIs, anticonvulsant and cytotoxic medications.21,22

  1. Pischon T, Hankinson SE, Hotamisligil GS, et al. Habitual dietary intake of omega-3 and omega-6 fatty acids in relation to inflammatory markers among US men and women. Circulation. 2003 Jul 15;108(2):155-60.
  2. Swanson D, Block R, Mousa SA. Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv Nutr. 2012;3:1-7.
  3. Wang C, Harris WS, Chung M, et al. n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondaryprevention studies: a systematic review. Am J Clin Nutr. 2006 Jul;84(1):5-17.
  4. Saito Y, Yokoyama M, Origasa H, et al. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis. 2008 Sep;200(1):135-40.
  5. Delgado-Lista J, Perez-Martinez P, Lopez-Miranda J, et al. Long chain omega-3 fatty acids and cardiovascular disease: a systematic review. Br J Nutr. 2012 Jun;107 Suppl 2:S201-13. doi:10.1017/S0007114512001596.
  6. Pottala JV, Garg S, Cohen BE, et al. Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study. Circ Cardiovasc Qual Outcomes. 2010 Jul;3(4):406-12.
  7. Casula M, Soranna D, Catapano AL, et al. Atheroscler Suppl. 2013 Aug;14(2):243-51.
  8. Tanaka K, Ishikawa Y, Yokoyama M, et al. Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: subanalysis of the JELIS trial. Stroke. 2008 Jul;39(7):2052-8.
  9. Yedgar S, Krimsky M, Cohen Y, et al. Treatment of inflammatory diseases by selective eicosanoid inhibition: a double-edged sword? Trends Pharmacol Sci. 2007 Sep;28(9):459-64.
  10. Schmitz G, Ecker J. The opposing effects of omega-3 and omega-6 fatty acids. Prog Lipid Res. 2008 Mar;47(2):147-55.
  11. Jung UJ, Torrejon C, Tighe AP, et al. n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects. Am J Clin Nutr. 2008 Jun;87(6):2003S-9S.
  12. Löfvenborg JE, Andersson T, Carlsson PO, et al. Fatty fish consumption and risk of latent autoimmune diabetes in adults. Nutr Diabetes. 2014 Oct 20;4:e139.
  13. Olsen SF, Østerdal ML, Salvig JD, et al. Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. Am J Clin Nutr. 2008 Jul;88(1):167-75.
  14. Proudman SM, James MJ, Spargo LD et al. Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use. Ann Rheum Dis. 2015 Jan;74(1):89-95.
  15. Romano C, Cucchiara S, Barabino A, et al. Usefulness of omega-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn's disease: a double-blind, randomized, placebo-controlled study. World J Gastroenterol. 2005 Dec 7;11(45):7118-21.
  16. Di Giuseppe D, Wallin A, Bottai M et al. Long-term intake of dietary long-chain n-3 polyunsaturated fatty acids and risk of rheumatoid arthritis: a prospective cohort study of women. Ann Rheum Dis. 2014 Nov;73(11):1949-53.
  17. Lorente-Cebrián S, Costa AG, et al. An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases. J Physiol Biochem. 2015 Mar 11. [Epub ahead of print]
  18. Bays HE. Safety considerations with omega-3 fatty acid therapy. Am J Cardiol. 2007 Mar 19;99(6A):35C-43C.
  19. Kromhout D, de Goede J. Update on cardiometabolic health effects of -3 fatty acids. Curr Opin Lipidol. 2014 Feb;25(1):85-90.
  20. Harris WS. Expert opinion: omega-3 fatty acids and bleeding-cause for concern? Am J Cardiol. 2007 Mar 19;99(6A):44C-46C.
  21. Toyama K, Nishioka T, Isshiki A, et al. Eicosapentaenoic Acid combined with optimal statin therapy improves endothelial dysfunction in patients with coronary artery disease. Cardiovasc Drugs Ther. 2014 Feb;28(1):53-9.
  22. Mischoulon D, Freeman MP. Omega-3 fatty acids in psychiatry. Psychiatr Clin North Am. 2013 Mar;36(1):15-23.  

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