Opti Ova™

Opti Ova™

Female Wellness Kit

1 Kit ( SKU: 9810 )

Benefits

  • Provides comprehensive nutritional support, with therapeutic dosages, for diverse factors affecting reproductive health
  • Broad spectrum antioxidants reduce oxidative stress and damage and enhance mitochondrial function, key determinants of oocyte function and quality
  • Provides the most bioavailable forms of nutrients, including pyridoxal 5-phosphate, mixed tocopherols, vitamin D3, methylcobalamin and L-5-methyltetrahydrofolate
  • Supports proper endometrial blood flow, supplying nutrients, removing toxins and reactive oxygen species (ROS) from the endometrium, encouraging proper implantation

Feature Summary

Opti Ova is a comprehensive female reproductive support kit that provides an effective combination of key antioxidants, omega-3 fatty acids, vitamins, and minerals proven to improve egg quality and enhance fertility. By optimizing mitochondrial function, reducing oxidative stress, supporting blood flow to the endometrium and its development, and enhancing detoxification pathways, Opti Ova provides a broad base of nutritional support for reproductive health. Mitochondrial activity is a key factor in oocyte function and quality, with mitochondrial dysfunction recognized as a major cause of age-induced decline in oocyte quality.1,2 Key nutrients, including PQQ, resveratrol, and CoQ10, have been shown to induce mitochondrial biogenesis,3 counteract ovarian aging4-6 and when combined with clomiphene citrate, CoQ10 supplementation resulted in a more than 6-fold increase in the clinical pregnancy rate than clomiphene alone, in a randomized prospective trial of participants with PCOS.7

N-acetylcysteine provides the limiting factor for glutathione production, essential for detoxification of many pollutants which interfere with reproductive function;8,9 it has also been shown to improve pregnancy rates and endometrial thickness when compared to standard treatments for PCOS, such as clomiphene and metformin.10

Opti Ova includes vitamins D and E, Ginkgo biloba, omega-3 fatty acids, lipoic acid, and bioavailable B vitamins which act as potent antioxidants and support optimal endometrial health and implantation.11 Vitamin E supplementation alone has been shown to shorten the time to pregnancy among women older than 35 seeking treatment for unexplained infertility, while vitamin D has been linked to implantation rates and IVF outcomes, with the highest levels linked to the highest pregnancy rates.12-15

Medicinal Ingredients

Serving Size: 1 Packet
Servings per Container: 60

Each Packet Contains

Vitamins:
Vitamin E (d-alpha Tocopherol) (Helianthus annuus) (seed) ............................ 405 IU (271.35 mg)
Vitamin D3 (Cholecalciferol)....................................................................... 1000 IU (25 mcg)
Vitamin B1 (Thiamine Hydrochloride)...............................................................................25 mg
Vitamin B2 (Riboflavin).................................................................................................. 10 mg
Niacin (Inositol Hexanicotinate)..................................................................................... 100 mg
Pantothenic Acid (Calcium d-Pantothenate) .................................................................. 100 mg
Vitamin B6 (Pyridoxal 5-Phosphate).............................................................................. 25 mg
Vitamin B12 (Methylcobalamin).................................................................................... 500 mcg
Quatrefolic® Folate (L-5-Methyltetrahydrofolate, Glucosamine Salt)................................ 400 mcg
Biotin............................................................................................................................ 250 mcg
Benfotiamine ................................................................................................................. 10 mg
Inositol ........................................................................................................................... 25 mg
Minerals:
Calcium (Citrate) ......................................................................................................... 350 mg
Additional Ingredients:
Coenzyme Q10 (Microorganism) ................................................................................. 260 mg
BioPQQ® Pyrroloquinoline Quinone (Pyrroloquinoline Quinone Disodium Salt)..................23.8 mg
Providing Pyrroloquinoline Quinone......................................................................... 20.98 mg
Japanese Knotweed Extract (Fallopia japonica) (root) (20% Trans-Resveratrol)...............66.67 mg
Grape Seed Extract (Vitis vinifera) (seed) (80% Oligomeric Proanthocyanidins) ..................30 mg
Ginkgo Biloba Extract (Ginkgo biloba) (leaf) (24% Flavonoid Glycosides, 6% Terpene Lactones)...80 mg
N-Acetyl-L-Cysteine ....................................................................................................... 250 mg
Acetylcarnitine (N-Acetyl L-Carnitine Hydrochloride)...........................................................300 mg
Alpha-Lipoic Acid (R-alpha-Lipoic Acid, Alpha-Lipoic Acid)..................................................350 mg
Fish Oil Concentrate (Molecularly Distilled, Ultra Purified)
(Anchovy, Sardine and/or Mackerel)...........................................................................1425 mg
Omega-3 Fatty Acids................................................................................................... 900 mg
Eicosapentaenoic Acid (EPA)........................................................................................ 600 mg
Docosahexaenoic Acid (DHA)....................................................................................... 300 mg
Choline (Dihydrogen Citrate) .......................................................................................... 50 mg

Mixed Vitamin E 400 IU (NPN 80064820)
Each Softgel Contains:
Vitamin E (d-alpha Tocopherol)..........................................400 IU (268 mg AT)
with Mixed Tocopherols: Beta, Delta and Gamma

Mito AMPTM (NPN 80044491)
Each Vegetarian Capsule Contains:
Acetylcarnitine (N-Acetyl L-Carnitine Hydrochloride).................... 300 mg
Ginkgo Biloba Extract (Ginkgo biloba) (leaf) (24% Flavonoid Glycosides, 6% Terpene Lactones)..80 mg
Japanese Knotweed Extract (Fallopia japonica) (root) (20% Trans-Resveratrol).........66.67 mg
Coenzyme Q10 (Microorganism)..................................................... 60 mg
R-Alpha-Lipoic Acid...................................................................... 50 mg
Grape Seed Extract (Vitis vinifera) (seed) (80% Oligomeric Proanthocyanidins)........... 30 mg
BioPQQ® Pyrroloquinoline Quinone (Pyrroloquinoline Quinone Disodium Salt)............3.8 mg
Providing Pyrroloquinoline Quinone ............................................3.33 mg

Calcium Citrate (NPN 80064605)
Each Tablet Contains:
Calcium (Citrate) ....................................................................... 350 mg

CerebroVital PQQ-10® (NPN 80052757)
Each Softgel Contains:
Coenzyme Q10 (Microorganism)................................................ 200 mg
BioPQQ® Pyrroloquinoline Quinone (Pyrroloquinoline Quinone Disodium Salt)......... 20 mg
Providing Pyrroloquinoline Quinone......................................17.65 mg
Sun-E 900 Vitamin E (d-alpha Tocopherol) (non-GMO Sunflower Oil)
(Helianthus annuus) (seed) ...........................................5 IU (3.35 mg AT)

OptiMega-3® with Vitamin D3 (NPN 80020906)
Each EnteripureTM Softgel Contains:
Fish Oil Concentrate (Molecularly Distilled, Ultra Purified)
(Anchovy, Sardine and/or Mackerel)…..............................1425 mg
Omega-3 Fatty Acids..........................................................900 mg
Eicosapentaenoic Acid (EPA)…......................................600 mg
Docosahexaenoic Acid (DHA)........................................ 300 mg
Vitamin D3 (Cholecalciferol) ...........................................1000 IU (25 mcg)

NAC &ALA (NPN 80055115)
Each Tablet Contains:
N-Acetyl-L-Cysteine................................................................. 250 mg
Alpha-Lipoic Acid.................................................................... 300 mg

B Complex-ProTM (NPN 80065324)
Each Vegetarian Capsule Contains:
Vitamin B1 (Thiamine Hydrochloride)...................................... 25 mg
Benfotiamine ............................................................................. 10 mg
Vitamin B2 (Riboflavin)............................................................ 10 mg
Niacin (Inositol Hexanicotinate).............................................. 100 mg
Pantothenic Acid (Calcium d-Pantothenate)............................. 100 mg
Vitamin B6 (Pyridoxal 5-Phosphate)......................................... 25 mg
Vitamin B12 (Methylcobalamin)............................................. 500 mcg
Quatrefolic® Folate (L-5-Methyltetrahydrofolate, Glucosamine Salt)..400 mcg
Biotin....................................................................................... 250 mcg
Choline (Dihydrogen Citrate)..................................................... 50 mg
Inositol........................................................................................ 25 mg

Non-Medicinal Ingredients

Mixed Vitamin E 400 IU
Softgel (gelatin, glycerin, purified water), soybean oil.

Mito AMPTM
Vegetarian capsule (carbohydrate gum [cellulose], purified water), silica, vegetable grade magnesium stearate (lubricant), microcrystalline cellulose.  

Calcium Citrate
Croscarmellose sodium, coating (carbohydrate gum [cellulose], glycerin), vegetable grade magnesium stearate (lubricant).

CerebroVital PQQ-10®
Softgel (gelatin, glycerin, purified water, carob), flaxseed oil, yellow beeswax, lecithin.

OptiMega-3® with Vitamin D3
EnteripureTM softgel (gelatin, glycerin, purified water, pectin), natural vitamin E.

NAC &ALA
Microcrystalline cellulose, dibasic calcium phosphate dihydrate, stearic acid, vegetable grade magnesium stearate (lubricant), coating (carbohydrate gum [cellulose], glycerin), silica, croscarmellose sodium.

B Complex-ProTM
Microcrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant).

Allergens:

Mixed Vitamin E 400 IU
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.

Mito AMPTM
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

Calcium Citrate
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

CerebroVital PQQ-10®
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.

OptiMega-3® with Vitamin D3
Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, egg, shellfish, salt, tree nuts, or GMOs.

NAC &ALA
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

B Complex-ProTM
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

Contraindications

Keep out of reach of children.

Mixed Vitamin E 400 IU
Consult a health care practitioner prior to use if you have cancer, cardiovascular disease, diabetes, or are taking blood thinners.

Mito AMPTM
Do not use if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you are taking medications for diabetes, high blood pressure, seizures, or if you have diabetes, a seizure disorder, liver or kidney disease, or have been instructed to follow a low protein diet. Do not use if you are taking health products with a blood coagulation affect (e.g., blood thinners, clotting factor replacements, acetylsalicylic acid, ibuprofen, fish oils, vitamin E) as this may increase the risk of spontaneous bleeding.

CerebroVital PQQ-10®
Consult a health care practitioner prior to use if you are pregnant or breastfeeding, or are taking blood pressure medication or blood thinners.  

NAC &ALA
Consult a health care practitioner prior to use if you are pregnant or breastfeeding, or if you have diabetes or kidney stones. Do not use this product if you are taking antibiotics or nitroglycerin.

B Complex-ProTM
People sensitive to nicotinic acid may experience flushing of the skin that is generally mild and transient.

  1. Schatten H, Sun QY, Prather R. The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility. Reprod Biol Endocrinol. 2014 Nov 24;12:111. doi: 10.1186/1477-7827-12-111.
  2. Oktay K, Baltaci V, Sonmezer M, et al. Oogonial Precursor Cell-Derived Autologous Mitochondria Injection to Improve Outcomes in Women With Multiple IVF Failures Due to Low Oocyte Quality: A Clinical Translation. Reprod Sci. 2015 Dec;22(12):1612-7. doi: 10.1177/1933719115612137.
  3. Chowanadisai W, Bauerly KA, Tchaparian E, et al. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010 Jan 1;285(1):142-52.
  4. Ben-Meir A, Burstein E, Borrego-Alvarez A., et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015 Oct;14(5):887-95.
  5. Özcan P, Fiçicioglu C, Kizilkale O, et al. Can Coenzyme Q10 supplementation protect the ovarian reserve against oxidative damage? J Assist Reprod Genet. 2016 Jun 3. [Epub ahead of print]
  6. Özcan P, Fiçicioglu C, Yildirim ÖK, et al. Protective effect of resveratrol against oxidative damage to ovarian reserve in female Sprague-Dawley rats. Reprod Biomed Online. 2015 Sep;31(3):404-10.
  7. El Refaeey A, Selem A, Badawy A. Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome. Reprod Biomed Online. 2014 Jul;29(1):119-24.
  8. Ziv-Gal A, Flaws JA. Evidence for bisphenol A-induced female infertility: review (2007-2016). Fertil Steril. 2016 Jul 11. pii: S0015-0282(16)61382-1.
  9. Jain S, Kumar CH, Suranagi UD, et al. Protective effect of N-acetylcysteine on bisphenol A-induced cognitive dysfunction and oxidative stress in rats. Food Chem Toxicol. 2011 Jun;49(6):1404-9.
  10. Maged AM, Elsawah H, Abdelhafez A, et al. The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome. Gynecol Endocrinol. 2015;31(8):635-8.
  11. Visioli F, Hagen TM. Antioxidants to enhance fertility: role of eNOS and potential benefits. Pharmacol Res. 2011 Nov;64(5):431-7.
  12. Ruder EH, Hartman TJ, Reindollar RH, et al. Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility. Fertil Steril. 2014 Mar;101(3):759-66.
  13. Farzadi L, Khayatzadeh Bidgoli H, Ghojazadeh M. et al. Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes. Iran J Reprod Med. 2015 Jun;13(6):361-6.
  14. Ozkan S, Jindal S, Greenseid K, et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 2010 Sep;94(4):1314-9.
  15. Paffoni A, Ferrari S, Viganò P, et al. Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. J Clin Endocrinol Metab. 2014 Nov;99(11):E2372-6.
  16. Kellermann AJ, Kloft C. Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. Pharmacotherapy. 2011 May;31(5):490-502. doi: 10.1592/phco.31.5.490.
  17. Kromhout D, de Goede J. Update on cardiometabolic health effects of ω-3 fatty acids. Curr Opin Lipidol. 2014 Feb;25(1):85-90.
  18. Diamond BJ, Bailey MR. Ginkgo biloba: indications, mechanisms, and safety. Psychiatr Clin North Am. 2013 Mar;36(1):73-83.
  19. Harris WS. Expert opinion: omega-3 fatty acids and bleeding-cause for concern? Am J Cardiol. 2007 Mar 19;99(6A):44C-46C.
  20. Toyama K, Nishioka T, Isshiki A, et al. Eicosapentaenoic Acid combined with optimal statin therapy improves endothelial dysfunction in patients with coronary artery disease. Cardiovasc Drugs Ther. 2014 Feb;28(1):53-9.
  21. Mischoulon D, Freeman MP. Omega-3 fatty acids in psychiatry. Psychiatr Clin North Am. 2013 Mar;36(1):15-23.