Inspir-Action™

Inspir-Action™

Helps Relieve Symptoms of Chronic Bronchitis

60 Tablets ( SKU: 9604, NPN: 80040826 )

Benefits

  • Provides mucolytic, demulcent and antitussive action for relief of cough, bronchitis, sinusitis, congestion and other respiratory conditions
  • Respiratory formula with unique combination of botanicals and nutrients designed to reduce symptoms and restore function
  • Clinically relevant dosages of each active ingredient
  • NAC also increases glutathione levels, a key antioxidant in lung tissues

Feature Summary

Inspir-Action provides a potent combination of nutrients and botanicals to provide symptom relief and improve respiratory function. N-acetyl-L-cysteine (NAC) is a well established mucolytic with the ability to break disulfide bonds, and has shown clinical benefit for individuals with COPD and pulmonary fibrosis.1,2 NAC has also been shown to attenuate symptoms of influenza-like infection, increase glutathione levels, inhibit activation of the inflammatory NF-κB pathway and modulate immune function.3,4,5

Proteolytic enzymes can also lower the viscosity of mucous secretions, and in a randomized trial bromelain reduced symptoms of acute sinusitis in children more effectively than standard therapy.6 Marshmallow is widely used for cough and soothing of irritated mucous membranes, with mucilaginous and bioadhesive effects attributed to polysaccharides extracted from the root.7 English ivy extract increases beta-2-adrenergic bronchial activity, relaxing smooth bronchial musculature and increasing surfactant factors and has proven an effective treatment for acute bronchitis.8 Extracts of mullein, wild cherry and horehound similarly have a long history of use for various respiratory tract pathologies, complementing this formula with a unique combination of demulcent, emollient, expectorant and antitussive properties to provide symptom relief.9

Medicinal Ingredients

Serving Size: 1 Tablet
Servings per Container: 60

Each Tablet Contains:
N-acetyl-L-cysteine....................................................................200 mg
Bromelain (Ananas comosus var. comosus) (stem)....................100 mg
(1 500 000 FCC PU*)
Marshmallow Extract 4:1 (Althaea officinalis) (root)................100 mg
Mullein Extract 4:1 (Verbascum thapsus) (leaf).........................100 mg
Wild Cherry Extract 4:1 (Prunus serotina) (bark)......................100 mg
Horehound Extract 4:1 (Marrubium vulgare) (herb)...................50 mg
Ivy Extract (Hedera helix) (leaf) 10% Hederacoside..................50 mg
*FCC: Food Chemical Codex, PU: Papain Unit

Non-Medicinal Ingredients

Microcrystalline cellulose, croscarmellose sodium, coating (carbohydrate gum [cellulose], glycerin), vegetable grade magnesium stearate (lubricant).

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, or GMOs. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

Consult a health care practitioner if symptoms persist and worsen. Do not use if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you have gastrointestinal lesions/ulcers, cystinuria, are taking anticoagulants/blood thinners, anti-inflammatory agents, antibiotics, nitroglycerin, hypoglycemic drugs, or are having surgery. Hypersensitivity/allergy has been known to occur, in which case discontinue use. Nausea, vomiting and diarrhea have been known to occur, in which case discontinue use and consult a health care practitioner. Keep out of reach of children.

Drug Interactions

Although NAC may reduce nitroglycerin tolerance and improve its efficacy for unstable angina, severe headaches and hypotension may occur. NAC may also reduce the capacity of activated charcoal to absorb acetaminophen. Bromelain may increase the concentration of several antibiotics and should be used with caution in patients on anticoagulants. Marshmallow may have a hypoglycemic effect, and should be used with caution with antidiabetic medications.

  1. Sutherland ER, Crapo JD, Bowler RP. N-acetylcysteine and exacerbations of chronic obstructive pulmonary disease. COPD. 2006 Dec;3(4):195-202.
  2. Demedts M, Behr J, Buhl R, et al., for the IFIGENIA Study Group. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med. 2005;353(21):2229–2242.
  3. Palacio JR, Markert UR, Martínez P. Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages. Inflamm Res. 2011 Jul;60(7):695-704.
  4. Zafarullah M, Li WQ, Sylvester J, et al. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci. 2003 Jan;60(1):6-20.
  5. De Flora S, Grassi C, Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur Respir J. 1997 Jul;10(7):1535-41.
  6. Braun JM, Schneider B, Beuth HJ. Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany. In Vivo. 2005 Mar-Apr;19(2):417-21.
  7. Deters A, Zippel J, Hellenbrand N, et al. Aqueous extracts and polysaccharides from Marshmallow roots (Althea officinalis L.): cellular internalisation and stimulation of cell physiology of human epithelial cells in vitro. J Ethnopharmacol. 2010 Jan 8;127(1):62-9.
  8. Cwientzek U, Ottillinger B, Arenberger P. Acute bronchitis therapy with ivy leaves extracts in a two-arm study. A double-blind, randomised study vs. an other ivy leaves extract. Phytomedicine. 2011 Oct 15;18(13):1105-9.
  9. Turker AU, Gurel E. Common mullein (Verbascum thapsus L.): recent advances in research. Phytother Res. 2005 Sep;19(9):733-9.