Healthworks Core 4 - DISCONTINUED

Healthworks Core 4 - DISCONTINUED

Daily Wellness Kit

1 Kit ( SKU: 9479, NPN: 80066658 )

Benefits

  • Each packet delivers daily dose of a full spectrum multiple vitamin and mineral, omega-3 fatty acids, and vitamins D and C
  • Provides rate limiting nutrients for glutathione production, necessary for xenobiotic detoxification
  • Pharmaceutical grade omega-3 blend USP standard verified for quality and consistency
  • This highly purified fish oil concentrate is free from lipid peroxides and environmental pollutants, including heavy metals, pesticides, dioxins, PCBs and other harmful compounds

Feature Summary

Healthworks’ Core 4 provides a unique combination of the most essential nutrients in a convenient packet for daily use. BioFoundation-G provides an optimal nutritional foundation of highly bioavailable nutrients at clinically relevant doses. These nutrients such as N-acetyl cysteine and R-alpha-lipoic acid, are well established to increase cellular levels of glutathione, the most prevalent intercellular antioxidant, and is one of the most important conjugators of numerous environmental and endogenous toxins. It is depleted not only by xenobiotics, but also by diabetes, and inflammatory and neurodegenerative diseases.1-9 BioFoundation-G contains therapeutic doses of milk thistle, CoQ10, vitamin K2, resveratrol, and other key nutrients that support mitochondrial function, and reduce inflammation and oxidative stress.10-17

Each packet also contains OptiMega-3 with Vitamin D3, among the most powerful nutrients for improving overall health as well as the most commonly deficient. EPA/DHA are known to lower atherosclerotic burden, reduce triglycerides and blood pressure, and improve platelet and vascular function.18-21 Vitamin D has been shown to modify cardiovascular risk, and reduce the risk of several cancers, autoimmune disease, osteoporotic fractures and overall mortality.22-26 It also provides 1000 mg of calcium ascorbate, a form of vitamin C known for its improved tolerability as well as greater bioavailability.27,28

Medicinal Ingredients

Serving Size: 1 Packet
Servings per Container: 60

Each Packet Contains:

BioFoundation-G™
Per Tablet
Vitamin A (Palmitate) ...................................... 150 mcg RAE (500 IU)
Vitamin B1 (Thiamine HCl) ...........................................4.2 mg
Vitamin B2 (Riboflavin) .................................................4.2 mg
Vitamin B3 (Niacin) .......................................................12.5 mg
Vitamin B3 (Niacinamide) ..............................................33.3 mg
Vitamin B5 (Pantothenic Acid) (Calcium-d-Pantothenate).......16.7 mg
Vitamin B6 (Pyridoxal 5-Phosphate) .....................................0.8 mg
Vitamin B6 (Pyridoxine HCl) ...............................................1.7 mg
Biotin .......................................................................... 8.3 mcg
Betaine HCl ....................................................................16.7 mg
Folate (Folic Acid) ........................................................... 83 mcg
Vitamin B12 (Methylcobalamin) ...................................... 167 mcg
Para-Aminobenzoic Acid (PABA)......................................4.2 mg
Choline (Bitartrate).............................................................4.2 mg
Inositol .........................................................................4.2 mg
Vitamin C (Ascorbic Acid) ...............................................167 mg
Vitamin D3 (Cholecalciferol) ..................................... 8.3 mcg (333 IU)
Gamma Tocopherol (Vitamin E) ......................................33.3 mg
Vitamin K2 (Menaquinone 7) ........................................... 7.5 mcg
Boron (Citrate) ............................................................. 41.7 mcg
Calcium (HVP* Chelate) .................................................16.7 mg
Chromium (Chromium Polynicotinate) ........................... 33.3 mcg
Copper (HVP* Chelate) ...................................................0.17 mg
Iodine (Ascophyllum nodosum) (whole plant)....................50 mcg
Magnesium (HVP* Chelate) ............................................33.3 mg
Manganese (Citrate) ..........................................................0.8 mg
Molybdenum (Citrate) .................................................. 66.7 mcg
Potassium (Citrate) ...........................................................6.8 mg
Selenium (Selenomethionine) ....................................... 33.3 mcg
Vanadium (Citrate) ......................................................... 2.5 mcg
Zinc (Citrate) ..................................................................2.5 mg
Bilberry Extract (Vaccinium myrtillus) (fruit) (25% Anthocyanidins).........6.6 mg
Citrus Bioflavonoids (Citrus limonum, Citrus sinensis, Citrus paradisi) (fruit) 4:1 Extract..8.3 mg
Coenzyme Q10 (Microorganism) ................................8.3 mg
Green Tea Phytosome® (Camellia sinensis) (leaf) (13% EGCg**) ........8.3 mg
Hesperidin (Citrus sinensis) (fruit) .............................4.2 mg
Lutein (flower) (10% Lutein) ....................................0.55 mg
Lycopene LYC-O-MATO® (Lycopersicon esculentum) (fruit) (5% Lycopene) ...0.28 mg
Milk Thistle Phytosome® (Silybum marianum) (seed) (15% Silybin) ..................25 mg
N-Acetyl Cysteine ............................................................25 mg
R-alpha-Lipoic Acid .....................................................41.7 mg
ResveratrolRich™ Proprietary Blend ..........................33.3 mg
[Wine Grape (Vitis vinifera) Powdered Extract (fruit) and Purified Japanese Knotweed (Polygonum cuspidatum) (root)
Providing Natural Trans-Resveratrol ..............................50 mg
*HVP: Hydrolyzed Vegetable Protein
**EGCg – epigallocatechin-3-0-gallate

OptiMega-3® with Vitamin D3
Each Softgel Contains:
Fish Oil Concentrate (Molecularly Distilled, Ultra Purified)
(Anchovy, Sardine and/or Mackerel) ..........................1407 mg
Omega-3 Fatty Acids .................................................900 mg
Eicosapentaenoic Acid (EPA) ..................................600 mg
Docosahexaenoic Acid (DHA) .................................300 mg
Vitamin D3 (Cholecalciferol) ......................................25 mcg (1000 IU)

Calcium Ascorbate
Each Capsule Contains:
Vitamin C (Calcium Ascorbate) .....................................820 mg
Calcium (Calcium Ascorbate) .........................................94 mg
Sourced from 1000 mg Calcium Ascorbate

Non-Medicinal Ingredients

BioFoundation-GTM
Microcrystalline cellulose, croscarmellose sodium, coating (carbohydrate gum [cellulose], glycerin), vegetable grade magnesium stearate (lubricant). / cellulose microcristalline, croscarmellose sodique, enrobage (gomme de glucides [cellulose], glycérine), stéarate de magnésium d’origine végétale (lubrifiant).

OptiMega-3® with Vitamin D3
Softgel (gelatin, glycerin, purified water), enteric coating (purified water, ethylcellulose, medium chain triglycerides, oleic acid, sodium alginate, stearic acid), natural vitamin E.

Calcium Ascorbate
Gelatin capsule (gelatin, purified water), vegetable grade magnesium stearate (lubricant).

Contraindications

While no specific contraindications are known, this product should be avoided by individuals with a history of hypersensitivity to any of its ingredients. Vitamin D supplementation should be done with caution in those with hypercalcemia, sarcoidosis, lymphoma, tuberculosis, hypercalcemia or renal impairment.29,30 Both benefit and risk of EPA/DHA supplementation has been documented for those at risk of or under treatment for cardiac arrhythmias, with close supervision indicated.31 This product does not contain iron, and may not be the most suitable for use during pregnancy and lactation. Not recommended for children under 12. Children over 12 can take half the recommended adult dose if able to swallow tablets.

Drug Interactions

Vitamin D may increase the risk for hypercalcemia when taken with a thiazide medication (diuretic).32 The antihypertensive effect of fish oil and/or vitamin D may potentially reduce the need or dosage for blood pressure medications, and patients should be closely monitored. Caution is advised for those on anticlotting, antiplatelet or anticoagulant medications, or those at high risk of bleeding.33,34 This product also contains nutrients known to affect blood glucose levels, and may require changes in dosing or discontinuation of related medications. Benefit has been shown when fish oil is taken in combination with statins, SSRIs, anticonvulsant and cytotoxic medications.35,36

  1. Atkuri KR, N-Acetylcysteine–a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9.
  2. Shay KP, et al. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009 Oct;1790(10):1149-60.
  3. Moraes TB, Dalazen GR, Jacques CE, et al. Glutathione metabolism enzymes in brain and liver of hyperphenylalaninemic rats and the effect of lipoic acid treatment. Metab Brain Dis. 2014 Sep;29(3):609-15.
  4. Awasthi YC, et al. Physiological and pharmacological significance of glutathione-conjugate transport. J Toxicol Environ Health B Crit Rev. 2009 Aug;12(7):540-51.
  5. Ludewig G et al. Mechanisms of toxicity of PCB metabolites: generation of reactive oxygen species and glutathione depletion. Cent Eur J Public Health. 2000 Jul;8 Suppl:15-7.
  6. Ahmed T, Endosulfan-induced apoptosis and glutathione depletion in human peripheral blood mononuclear cells: Attenuation by N-acetylcysteine. J Biochem Mol Toxicol. 2008 Sep;22(5):299-304.
  7. Lee DH, et al. Serum gamma-glutamyltransferase: new insights about an old enzyme. J Epidemiol Community Health. 2009 Nov;63(11):884-6.
  8. Treweeke AT, Winterburn TJ, Mackenzie I, et al. N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial. Diabetologia. 2012 Nov;55(11):2920-8. doi: 10.1007/s00125-012-2685-z.
  9. Ljubisavljevic S, Stojanovic I, Cvetkovic T, et al. Glutathione homeostasis disruption of erythrocytes, but not glutathione peroxidase activity change, is closely accompanied with neurological and radiological scoring of acute CNS inflammation. Neuroimmunomodulation. 2014;21(1):13-20.
  10. Rosenfeldt F, Marasco S, Lyon W, et al. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. J Thorac Cardiovasc Surg. 2005 Jan;129(1):25-32.
  11. Kiruthiga PV, Shafreen RB, Pandian SK, et al. Silymarin protection against major reactive oxygen species released by environmental toxins: exogenous H2O2 exposure in erythrocytes. Basic Clin Pharmacol Toxicol. 2007 Jun;100(6):414-9.
  12. Schurgers LJ, et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007 Apr 15;109(8):3279-83.
  13. Logan VF, Gray AR, Peddie MC, et al. Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25-hydroxyvitamin D status over the winter months. Br J Nutr. 2013 Mar 28;109(6):1082-8. doi: 10.1017/S0007114512002851.
  14. Baur JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-42.
  15. Fröjdö S, et al. Metabolic effects of resveratrol in mammals--a link between improved insulin action and aging. Curr Aging Sci. 2008 Dec;1(3):145-51.
  16. Brasnyó P, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr. 2011 Mar 9:1-7. [Epub ahead of print].
  17. Di Pierro F, Menghi AB, Barreca A, et al. Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Altern Med Rev. 2009 Jun;14(2):154-60.
  18. Pischon T, Hankinson SE, Hotamisligil GS, et al. Habitual dietary intake of omega-3 and omega-6 fatty acids in relation to inflammatory markers among US men and women. Circulation. 2003 Jul 15;108(2):155-60.
  19. Swanson D, Block R, Mousa SA. Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv Nutr. 2012;3:1-7.
  20. Wang C, Harris WS, Chung M, et al. n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Am J Clin Nutr. 2006 Jul;84(1):5-17.
  21. Saito Y, Yokoyama M, Origasa H, et al. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis. 2008 Sep;200(1):135-40.
  22. Muscogiuri G, Sorice GP, Ajjan R, Mezza T, Pilz S, Prioletta A, Scragg R, Volpe SL, Witham MD, Giaccari A. Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives. Nutr Metab Cardiovasc Dis. 2012 Feb;22(2):81-7.
  23. Fletcher JM, Basdeo SA, Allen AC, Dunne PJ. Therapeutic use of vitamin D and its analogues in autoimmunity. Recent Pat Inflamm Allergy Drug Discov. 2012 Jan;6(1):22-34.
  24. Baz-Hecht M, Goldfine AB. The impact of vitamin D deficiency on diabetes and cardiovascular risk. Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):113-9.
  25. Zittermann A, Prokop S. The role of vitamin D for cardiovascular disease and overall mortality. Adv Exp Med Biol. 2014;810:106-19.
  26. Chowdhury R, Kunutsor S, Vitezova A, et al. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014 Apr 1;348:g1903. doi: 10.1136/bmj.g1903.
  27. Gruenwald J, Graubaum HJ, Busch R Safety and tolerance of ester-C compared with regular ascorbic acid. Adv Ther. 2006 Jan-Feb;23(1):171-8.
  28. Cai J, Zhang Q, Wastney ME, Weaver CM. Calcium bioavailability and kinetics of calcium ascorbate and calcium acetate in rats. Exp Biol Med (Maywood). 2004 Jan;229(1):40-5.
  29. Sage RJ, Rao DS, Burke RR, Lim HW. Preventing vitamin D toxicity in patients with sarcoidosis. J Am Acad Dermatol. 2011 Apr;64(4):795-6.
  30. Bevilacqua M, Dominguez LJ, Gandolini G, et al. Vitamin D substrate-product relationship in idiopathic hypercalciuria. J Steroid Biochem Mol Biol. 2009 Jan;113(1-2):3-8.
  31. Kromhout D, de Goede J. Update on cardiometabolic health effects of -3 fatty acids. Curr Opin Lipidol. 2014 Feb;25(1):85-90.
  32. Boulard JC, Hanslik T, Alterescu R, Baglin A. [Symptomatic hypercalcemia after vitamin D-thiazide diuretics combination. Two cases in elderly women]. Presse Med. 1994 Jan 22;23(2):96.
  33. Harris WS. Expert opinion: omega-3 fatty acids and bleeding-cause for concern? Am J Cardiol. 2007 Mar 19;99(6A):44C-46C.
  34. Ford SK, Misita CP, Shilliday BB, et al. Prospective study of supplemental vitamin K therapy in patients on oral anticoagulants with unstable international normalized ratios. J Thromb Thrombolysis. 2007 Aug;24(1):23-7.
  35. Toyama K, Nishioka T, Isshiki A, et al. Eicosapentaenoic Acid combined with optimal statin therapy improves endothelial dysfunction in patients with coronary artery disease. Cardiovasc Drugs Ther. 2014 Feb;28(1):53-9.
  36. Mischoulon D, Freeman MP. Omega-3 fatty acids in psychiatry. Psychiatr Clin North Am. 2013 Mar;36(1):15-23.