Clear-HM™

Clear-HM™

Complete Detoxification Support

180 Vegetarian Capsules ( SKU: 9220, NPN: 80033669 )

Benefits

  • Comprehensive support for the detoxification of heavy metals
  • Contains nutrients which increase the synthesis and regeneration of glutathione, a potent detoxifier of reactive oxygen species and heavy metals
  • Provides diverse antioxidant support as well as neurological, renal and hepatoprotective nutrients
  • Highly bioavailable minerals supply detoxification enzyme cofactors which are often deficient

Feature Summary

Clear-HM provides advanced heavy metal detoxification support, supplying nutrients which increase glutathione levels, assist in heavy metal removal, improve antioxidant status, and protect against cellular and hepatic damage. N-acetyl cysteine (NAC) and alpha-lipoic acid both increase cellular levels of glutathione, which binds to mercury and reactive oxygen species and participates in the detoxification of many xenobiotics via conjugation reactions.1-5 They are powerful antioxidants and have been found to reduce toxicity to multiple organs from lead, arsenic, mercury, and cadmium.6,7,8

Spirulina platensisis a potent free radical scavenger, found to protect against heavy metal induced organ damage and to prevent anemia, leukopenia and the deposition of heavy metals in the brain.9-12 Spirulina also contains significant amounts of alkaline phosphatase activity, which may assist in the detoxification of organophosphorus pesticides.13 Vitamins B6 and C are required for the synthesis or regeneration of glutathione, with the latter providing broad antioxidant support minimizing heavy metal toxicity.14,15 Milk thistle is a well-established hepatoprotectant, and magnesium, often deficient in those with toxin exposure, provides an essential cofactor for many detoxification and mitochondrial enzymes.16,17

Medicinal Ingredients

Serving Size: 2 Vegetarian Capsules
Servings per Container: 90

Each Capsule Contains:
Vitamin C (Ascorbic Acid) .............................................................................166.6 mg
Milk Thistle Extract (Silybum marianum) (seed) (60% Silymarin)..............116.7 mg
Organic Spirulina platensis Powder (whole cell)........................................83.3 mg
DL-Alpha-Lipoic Acid ..................................................................................66.6 mg
Magnesium (Citrate)....................................................................................53.3 mg
N-Acetyl-L-Cysteine....................................................................................41.6 mg
Selenium (Selenomethionine).................................................................. 16.6 mcg
Vitamin B6 (Pyridoxine Hydrochloride).....................................................4.16 mg
Zinc (Gluconate)...............................................................................................0.66 mg

Non-Medicinal Ingredients

Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), modified citrus pectin.

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, or GMOs. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

Consult a health care practitioner prior to use if you are pregnant or breastfeeding, if you have diabetes or cystinuria, or if you are taking antibiotics or nitroglycerin. Consult a health care practitioner if symptoms persist or worsen. Hypersensitivity is known to occur, in which case discontinue use. Keep out of reach of children.

Drug Interactions

This product contains nutrients known to reduce hypertension and hyperglycemia, and may require lower dosing or discontinuation of related medications.

  1. Franco R, et al. The central role of glutathione in the pathophysiology of human diseases. Arch Physiol Biochem. 2007 Oct-Dec;113(4-5):234-58.
  2. Shay KP, et al. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009 Oct;1790(10):1149-60.
  3. Atkuri KR. N-Acetylcysteine–a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9.
  4. Becker A, et al. The role of intracellular glutathione in inorganic mercury-induced toxicity in neuroblastoma cells. Neurochem Res. 2009 Sep;34(9):1677-84.
  5. Kasperczyk S, Dobrakowski M, Kasperczyk A, et al. Effect of treatment with N-acetylcysteine on non-enzymatic antioxidant reserves and lipid peroxidation in workers exposed to lead. Ann Agric Environ Med. 2014;21(2):272-7. doi: 10.5604/1232-1966.1108590.
  6. Flora SJ. Heavy metal induced oxidative stress &its possible reversal by chelation therapy. Indian J Med Res. 2008.
  7. Wang L et al. Protective effect of N-acetylcysteine on experimental chronic cadmium nephrotoxicity in immature female rats. Hum Exp Toxicol. 2009.
  8. Aremu DA, et al. N-acetylcysteine as a potential antidote and biomonitoring agent of methylmercury exposure. Environ Health Perspect. 2008 Jan;116(1):26-31.
  9. Kalafati M, et al. Ergogenic and antioxidant effects of spirulina supplementation in humans. Med Sci Sports Exerc. 2010 Jan;42(1):142-51.
  10. Ponce-Canchihuamán JC, et al. Protective effects of Spirulina maxima on hyperlipidemia and oxidative-stress induced by lead acetate in the liver and kidney. Lipids Health Dis. 2010 Mar 31;9:35.
  11. Karadeniz A, et al. The effects of Panax ginseng and Spirulina platensis on hepatotoxicity induced by cadmium in rats. Ecotoxicol Environ Saf. 2009 Jan;72(1):231-5.
  12. Hosseini SM, Khosravi-Darani K, Mozafari MR. Nutritional and medical applications of spirulina microalgae. Mini Rev Med Chem. 2013 Jun 1;13(8):1231-7.
  13. Thengodkar RR, et al. Degradation of Chlorpyrifos by an alkaline phosphatase from the cyanobacterium Spirulina platensis. Biodegradation. 2010 Jul;21(4):637-44.
  14. Depeint F, et al. Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways. Chem Biol Interact. 2006 Oct 27;163(1-2):113-32.
  15. Rendón-Ramírez AL, Maldonado-Vega M, Quintanar-Escorza MA, et al. Effect of vitamin E and C supplementation on oxidative damage and total antioxidant capacity in lead-exposed workers. Environ Toxicol Pharmacol. 2014 Jan;37(1):45-54.
  16. Kiruthiga PV, Shafreen RB, Pandian SK, et al. Silymarin protection against major reactive oxygen species released by environmental toxins: exogenous H2O2 exposure in erythrocytes. Basic Clin Pharmacol Toxicol. 2007 Jun;100(6):414-9.
  17. Srivastava D, et al. Protective effects of selenium, calcium, and magnesium against arsenic-induced oxidative stress in male rats. Arh Hig Rada Toksikol. 2010 Jun 1;61(2):153-9.