Arthro NRx™

Arthro NRx™

Eases Osteoarthritic Symptoms

60 Tablets ( SKU: 9242, NPN: 80045358 )

Benefits

  • Two months of treatment with standardized boswellia in those with OA resulted in a decrease in knee pain and swelling along with an increase knee flexion and greater walking distance6
  • Unlike placebo, those with painful hip or knee OA who took 300 mg of avocado soybean unsaponifiables (ASU) daily for 6 months, experienced a significant reduction in pain and improved their overall functional abilities7
  • Calcium fructoborate has been shown in those with OA to decrease inflammatory biomarkers such as C-reactive protein, fibrinogen and erythrocyte sedimentation rate8
  • Meta-analysis indicates that rosehip powder reduces pain in patients with knee OA9
  • InflamRelief, a unique combination of fruit extracts, helps decrease inflammatory cytokines10
  • Curcumin helps reduce knee OA pain.11,12,13 Theracurmin, a proprietary micronized curcumin, exhibits superior bioavailability to curcumin powder.
  • Glucosamine and chondroitin sulfate are chondroprotective, the primary ingredients of cartilage, stimulating the process of the cartilage metabolism14
  • Hyaluronic acid has shown improved activity daily living scores in those with knee OA15

Feature Summary

With the population aging and the life expectancy extending, osteoarthritis (OA) will be the fourth leading cause of disability by the year 2020.1 The Centers for Disease Control in the United States notes that one in two Americans will get some form of OA in their lifetime and 27 million adults currently have it.2 OA induced joint damage is responsible for more than 90 per cent of the knee replacement surgeries in Canada.3 Although surgical interventions are employed in hip and knee OA patients who are refractory to other types of more conservative management techniques, it is considered to be a last resort option.4

Arthro NRx provides a well researched and less risky option to prescription agents. Chondroprotective agents such as glucosamine sulfate, MSM and chondroitin sulfate are well known for the treatment of OA. Combinations of these agents have been shown to be more clinically advantageous than single product use. In one study, 118 patients with moderate knee OA, the combination of 1,500 mg glucosamine plus 1,500 mg MSM per day for 12 weeks provided better pain relief and less swelling than those who took glucosamine or MSM alone.5

Medicinal Ingredients

Serving Size: 3 Tablets
Servings per Container: 20

Each Tablet Contains:
Glucosamine Sulfate (Potassium Chloride from crab/shrimp exoskeleton)..........250 mg
MSM (Methylsulfonylmethane)..............................................................................200 mg
Chondroitin Sulfate (Bovine Cartilage)...............................................................133.3 mg
Boswellia Extract (Boswellia serrata, gum oleoresin) (60% Boswellic Acids).......66.6 mg
TheracurminTM (Curcuma longa) (Extract providing 8.5% curcumin).......................50 mg
AvoVidaTM Avocado/Soy Non-GMO Unsaponifiables (Persea gratissima, fruit)
(Glycine max, seed) [Standardized to minimum 30% Phytosterols]..........................50 mg
Hyaluronic Acid (Sodium Hyaluronate)....................................................................6.6 mg
Vitamin C (Dog Rose Extract 20:1 [Rosa canina] [fruit]).........................................6.6 mg
InflamReliefTM Complex (Fruit blend).......................................................................3.3 mg
Proprietary Blend of: Grape (Vitis vinifera), Pomegranate (Punica granatum), Strawberry (Fragaria vesca), Cranberry (Vaccinium macrocarpon), Blueberry (Vaccinium corymbosum), Raspberry (Rubus idaeus), Bilberry (Vaccinium myrtillus) [Standardized to 76% Polyphenols]
Manganese (Citrate).............................................................................................0.33 mg
Boron (Calcium Fructoborate)............................................................................116.6 mcg

Non-Medicinal Ingredients

Microcrystalline cellulose, croscarmellose sodium, coating (carbohydrate gum [cellulose], maltodextrin, medium chain triglycerides), vegetable grade magnesium stearate (lubricant).

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, egg, fish, salt, or tree nuts. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

Consult a health care practitioner if symptoms worsen. Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Some people may experience mild gastrointestinal effects such as diarrhea, abdominal pain/cramps and nausea. Hypersensitivity has been known to occur, in which case discontinue use. Keep out of reach of children.

Drug Interactions

Anticoagulants such as warfarin.16,17

  1. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bulletin of the World Health Organization. 2003;81:646-656.
  2. http://www.cdc.gov/features/osteoarthritisplan/
  3. http://www.arthritis.ca/document.doc?id=338
  4. Seed SM, et al. Osteoarthritis: a review of the treatment options. Modern Medicine. 2009. http://www.modernmedicine.com/modernmedicine/Modern+Medicine+Now/Osteoarthritis-A-review-of-treatment-options/ ArticleStandard/Article/detail/596636?contextCategoryId=40148.
  5. Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their combination in Osteoarthritis. Clin Drug Investig. 2004;24:353-63.
  6. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–a randomized double blind placebo controlled trial. Phytomedicine. 2003;10:3-7.
  7. Maheu E, Mazières B, Valat JP, Loyau G, Le Loët X, Bourgeois P, Grouin JM, Rozenberg S. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month follow up demonstrating a persistent effect. Arthritis Rheum. 1998;41:81-91.
  8. Scorei R, Mitrut P, Petrisor I, Scorei I. A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis. Biol Trace Elem Res. 2011;144:253-63.
  9. Christensen R, Bartels EM, Altman RD, Astrup A, Bliddal H. Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?–a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2008;16:965-72.
  10. González-Gallego J, García-Mediavilla MV, Sánchez-Campos S, Tuñón MJ. Fruit polyphenols, immunity and inflammation. Br J Nutr. 2010;104 Suppl 3:S15-2.
  11. Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011;34:660-5.
  12. Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L, Thamlikitkul V. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J Altern Complement Med. 2009;15:891-7.
  13. Mathy-Hartert M, Jacquemond-Collet I, Priem F, Sanchez C, Lambert C, Henrotin Y. Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm Res. 2009;58:899-908.
  14. Jerosch J. Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. Int J Rheumatol. 2011;2011: 969012.
  15. Sato T, Iwaso H. An Effectiveness Study of Hyaluronic acid Hyabest® in the Treatment of Osteoarthritis of the Knee on the Patients in the United States. J.New Rem &Clin. 2009;58:200e.
  16. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57:1221-7.
  17. Knudsen JF, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database. Pharmacotherapy. 2008;28:540-8.