Allerieva®

Allerieva®

Helps Relieve Seasonal Allergy Symptoms

60 ( SKU: 9603, NPN: 80074182 )

Benefits

  • Vitamin C has been shown to decrease blood histamine levels
  • Vitamin C also raises glutathione levels by 50%.5,6 Increasing this potent antioxidant may help reduce nasal obstruction, rhinorrhea and ear fullness.7
  • EMIQ (enzymatically modified isoquercitrin) has been shown to reduce ocular allergic symptoms in those with pollinosis8
  • EMIQ is prepared by using a natural enzyme process that attaches polysaccharides to convert quercetin into a soluble form. According to pharmacokinetic data, the absorption of EMIQ is up to 40 times greater (Cmax) and 15 times greater (AUC) than quercetin.
  • The patented bioflavonoid pycnogenol, when given 5 weeks before birch allergy season, reduced eye and nasal symptoms by 35% and 19.5% respectively9
  • Stinging nettle leaf has been shown in vitro to inhibit the pro-inflammatory pathways related to allergic rhinitis.10 Urtica is a potent 4:1 extract.  
  • Suitable for vegetarians/vegans

Feature Summary

Allergic rhinitis is a common upper respiratory problem seen routinely in clinical practice. This problem occurs when inhaled allergens come in contact with IgE antibodies on the surface of the airway triggering numerous acute symptoms: nasal congestion, sneezing, a watery ocular discharge, rhinnorea, and a pruritic palate along with sinus and eustachian tube congestion.1 According to the Centers for Disease Control (CDC) in the United States, 17.9 million adults and 7.1 million children were diagnosed with hay fever in the year 2010.2 While numerous prescription and over the counter (OTC) antihistamines can benefit by relieving symptoms, they are often fraught with side effects including dry mouth, sleepiness, and restlessness. Allerieva represents an alternative that is safe for both short and long term use. A recent controlled study concluded that 2000 mg per day of the blue green algae spirulina significantly reduced the symptoms of allergic rhinitis including nasal discharge, sneezing, nasal congestion, and itching after three weeks of use.3 In humans, spirulina acts on hay fever symptoms by significantly reducing the secretion of an inflammatory cytokine IL-4 by 32%.4

Medicinal Ingredients

Serving Size: 2 Vegetarian Capsules
Servings per Container: 30

Each Capsule Contains:
Organic Spirulina (Spirulina platensis) (whole)................................335 mg
Vitamin C (Calcium Ascorbate).......................................................175 mg
Stinging Nettle 4:1 Extract (Urtica dioica) (leaf)...............................50 mg
Pycnogenol® (French Maritime Pine Bark Extract)
(Pinus pinaster) (bark) (65-75% Procyanidins)................................17 mg
EMIQ (Enzymatically Modified Isoquercitrin)..................................50 mg
(Providing 15 mg of Highly Absorbable Quercetin)

Non-Medicinal Ingredients

Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, silica, vegetable grade magnesium stearate (lubricant).

Allergens:

Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

Do not use if you are pregnant or breastfeeding or have any known allergy to any of the ingredients in this product. Consult a health care practitioner if symptoms persist or worsen. Stop this product 1 week prior to surgery.11 Keep out of reach of children.

Drug Interactions

Do not take concurrently with Ciprofloxacin, Bortezomid or Warfarin.12,13,14

  1. Plaut M, Valentine MD. Allergic rhinitis. N Eng J Med 2005;353:1934-44.
  2. http://www.cdc.gov/nchs/fastats/allergies.htm Accessed on Sept 10th, 2012
  3. Cingi C, Conk-Dalay M, Cakli H, Bal C. The effects of spirulina on allergic rhinitis. Eur Arch Otorhinolaryngol. 2008;265:1219-23.
  4. Mao TK, Van de Water J, Gershwin ME. Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients. J Med Food. 2005;8:27-30.
  5. Johnston CS. The antihistamine action of ascorbic acid. Subcell Biochem. 1996;25:189-213.
  6. Johnston CS, Meyer CG, Srilakshmi JC. Vitamin C elevates red blood cell glutathione in healthy adults. Am J Clin Nutr. 1993;58:103-5.
  7. Testa B, Mesolella M, Testa D, Giuliano A, Costa G, Maione F, Iaccarino F. Glutathione in the upper respiratory tract. Ann Otol Rhinol Laryngol. 1995;104:117-9.
  8. Kawai M, Hirano T, Arimitsu J, Higa S, Kuwahara Y, Hagihara K, Shima Y, Narazaki M, Ogata A, Koyanagi M, Kai T, Shimizu R, Moriwaki M, Suzuki Y, Ogino S, Kawase I, Tanaka T. Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial. Int Arch Allergy Immunol. 2009;149:359-68.
  9. Wilson D, Evans M, Guthrie N, Sharma P, Baisley J, Schonlau F, Burki C. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 2010;24:1115-9.
  10. Roschek B Jr, Fink RC, McMichael M, Alberte RS. Nettle extract (Urtica dioica) affects key receptors and enzymes associated with allergic rhinitis. Phytother Res. 2009;23:920-6.
  11. Golanski J, Muchova J, Golanski R, Durackova Z, Markuszewski L, Watala C. Does pycnogenol intensify the efficacy of acetylsalicylic acid in the inhibition of platelet function? In vitro experience. Postepy Hig Med Dosw (Online). 2006;60:316-21.
  12. Masadeh MM, Mhaidat NM, Alzoubi KH, Al-Azzam SI, Shaweesh AI. Ciprofloxacin-induced antibacterial activity is reversed by vitamin E and vitamin C. Curr Microbiol. 2012 May;64:457-62.
  13. Perrone G, Hideshima T, Ikeda H, Okawa Y, Calabrese E, Gorgun G, Santo L, Cirstea D, Raje N, Chauhan D, Baccarani M, Cavo M, Anderson KC. Ascorbic acid inhibits antitumor activity of bortezomib in vivo. Leukemia. 2009;23:1679-86.
  14. Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA. 1972 Mar 13;219(11):1479.
  15. Di Bari L, Ripoli S, Pradhan S, Salvadori P. Interactions between quercetin and warfarin for albumin binding: A new eye on food/drug interference. Chirality. 2010;22:593-6.